Results 131 to 140 of about 939,166 (317)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Accessibility Subcommittee makes recommendations on live captioning

open access: yes, 2019
The ISR/DACCD Accessibility Subcommittee offers guidance on live captioning options for webinars and live events, exploring costs and logistics.https://deepblue.lib.umich.edu/bitstream/2027.42/152322/1/2019 Live Captioning White Paper-adacompliant ...
Accessibility Subcommittee, ISR DACCD
core  

Digital Accessibility Symposium

open access: yes, 2023
The Colleague Disability Network organised a Digital Accessibility Symposium on the 1st of December, welcoming approximately forty attendees from across the Higher Education sector and wider industry (including the National Health Service and Unilever ...
de Silva, D.   +3 more
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A weighted-fusion assisted monitoring system for disabled people leveraging EfficientNet and VGG16 collaboration

open access: yesDiscover Applied Sciences
The intensification of global aging and the continuous expansion of the disabled population have put forward an urgent need for their daily safety supervision.
Xinyuan Zhang, Wanbing Shi
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Testing the Temporal Stability of Accessibility Value in Residential Hedonic Prices [PDF]

open access: yes
Purpose – This paper bridges the gap between, on the one hand, supply-driven (urban form and transportation networks) and demand-driven (action-based) accessibility to urban amenities and, on the other hand, house price dynamics as captured through panel
Francois Des Rosiers   +2 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Open accessibility data interlinking

open access: yes
This paper presents the research of using Linked Open Data to enhance accessibility data for accessible travelling. Open accessibility data is the data related to the accessibility issues associated with geographical data, which could benefit people with
Ding, Chaohai, Wald, Mike, Wills, Gary
core  

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