Results 81 to 90 of about 1,878,438 (308)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Planning virtual and hybrid events: steps to improve inclusion and accessibility [PDF]

Geoscience Communication
The past decade has seen a global transformation in how we communicate and connect with one another, making it easier to network and collaborate with colleagues worldwide. The COVID-19 pandemic led to a rapid and unplanned shift toward virtual platforms,
A. L. Doran, A. L. Doran, V. Dutch, V. Dutch, B. Warren, R. A. Watson, R. A. Watson, K. Murphy, A. Aldis, I. Cooper, C. Cockram, D. Harp, M. Desmau, M. Desmau, L. Keppler, L. Keppler   +15 more
doaj   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Effects of lighting variability on locomotion in posterior cortical atrophy

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Clinical reports describe patients with Alzheimer's disease (AD) exhibiting atypical adaptive walking responses to the visual environment; however, there is limited empirical investigation of such behaviors or factors modulating their ...
Keir X. X. Yong, Ian D. McCarthy, Teresa Poole, Dilek Ocal, Ayako Suzuki, Tatsuto Suzuki, Kyriaki Mengoudi, Nikolaos Papadosifos, Derrick Boampong, Nick Tyler, Chris Frost, Sebastian J. Crutch   +11 more
doaj   +1 more source

Concepts, reflections and applications of social equity: approaches to accessibility to primary goods and services in the region of Flanders, Belgium [PDF]

, 2015
Mobility presents a variety of opportunities as it allows users to access locations and services, and to meet people beyond their immediate surroundings.
De Maeyer, Philippe, Deruyter, Greet, Fransen, Koos   +2 more
core   +2 more sources

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Access and Accessibility in E-Learning

, 2009
This chapter considers some of the major questions around access and accessibility, beginning with the most basic: just what is meant by access and how this relates to the notion of accessibility since the assumption is so frequently made that we all know so much what access and accessibility are that few writers ever bother to define them or even to ...
Matheson, C, Matheson, D.
openaire   +2 more sources

On accessible groups

Journal of Pure and Applied Algebra, 1976
The factors X (and Y) are easily seen to be finitely generated. Stalling’s result is usually stated for groups with infinitely many ends, but a group with two ends satisfies either (a) with K of index two in X and Y or (0) with K = L = X (see [6] ). In (0) it is allowed that X = ( 1).
M.J. Dunwoody, C. Bamford
openaire   +2 more sources