Results 101 to 110 of about 2,106,065 (283)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

ACCESSIBLE BUILT ENVIRONMENT FOR THE ELDERLY AND DISABLED IN MALAYSIA: HOTELS AS CASE STUDIES [PDF]

Journal of Construction in Developing Countries, 2010
In Malaysia, it has become of increasing importance to study ways to improve the level of accessibility in buildings for the elderly and disabled people in the built environment, especially in hotels and resorts.
Asiah Abdul Rahim, Nur Amirah Abd. Samad
doaj  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Developing accessible routes in historic environments for wheelchair users using a smart mobile application

Ain Shams Engineering Journal
In cities with historical heritage, wheelchair users cannot benefit from urban spaces due to the lack of design in the physical environment. In this study, Konya city centre (Turkey), which has a historical richness for the solution of this problem, is ...
Hüseyin Özdemir
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Generating Virtual Environments to Allow Increased Access to the Built Environment

International Journal of Virtual Reality, 1998
The problems encountered by individuals with disabilities when accessing large public buildings is described and a solution based on the generation of virtual models of the built environment is proposed. These models are superimposed on a control network infrastructure, currently utilised in intelligent building applications such as lighting, heating ...
T. Foster, G., E N Wenn, D, S. Harwin, W., O'Hart, F.   +3 more
openaire   +3 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

My Home is My Post-Office: Evaluation of a decentralized email architecture on Internet-of-Things low-end device

, 2017
Users predominantly access their email via mobile devices. This presents a two-fold challenge to the email applications. First, email's update from multiple devices has to be eventually reconciled with the server.
Crowcroft, Jon, Tsipenyuk, Gregory
core   +1 more source

Radio Access Network Behavior In Urban Environment

, 2017
The exponential grow of data traffic, sets stringent requirements for future generation networks. The study of the existing networks allows to understand important factors for the design of the future networks. Moreover , the LTE network is going to be part of the next generation infrastructure until new infrastructures have covered all areas.
Matzoros, Panagiotis, Tsirakis, Christos, Agapiou, George   +2 more
openaire   +1 more source