Results 111 to 120 of about 2,106,065 (283)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Property of various correlation measures of open Dirac system with Hawking effect in Schwarzschild space–time

open access: yesPhysics Letters B, 2015
We explore the performance of various correlation measures for open Dirac system with Hawking effect in Schwarzschild space–time. Our results indicate that the impact of Hawking effect on physical accessible entanglement is weaker than that of ...
Juan He, Shuai Xu, Yang Yu, Liu Ye
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Family farming an asset for the planet ... : Food security, biodiversity, climate, water, jobs, environment... family farms are tackling the challenges of the future! [PDF]

open access: yes, 2014
Over its fifteen pages or so, the 2014 edition of the CIRAD brochure produced for the Paris International Agricultural Show illustrates to what extent and in what way family farming can address the challenges of providing jobs and alleviating poverty ...
Causse, Frédérique (ed.)   +3 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Investment Assessments in the Adoption of Accessible and Assistive Technologies Within Built Environments for Persons with Disabilities

open access: yesBuildings
Emerging trends in technology are providing opportunities for a broader range of accessible and assistive technologies (AATs) to positively impact persons with disabilities in terms of independent living and employment within and across built ...
Siny Joseph, Vinod Namboodiri
doaj   +1 more source

PIR Sensors Deployment with the Accessible Priority in Smart Home Using Genetic Algorithm

open access: yesInternational Journal of Distributed Sensor Networks, 2015
In smart home, location estimation based on PIR sensors is very popular. Existing methods by various sensors technologies and intelligent algorithms are used to achieve a high accuracy.
Dan Yang   +3 more
doaj   +1 more source

ACCESSIBLE GUIDELINES ON DIGITAL ENVIRONMENTS

open access: yesErgodesign & HCI, 2016
This article presents a reflection on design in front of users with special needs. Promotes a bibliographical and technical survey of graphic parameters for sites. Guidelines of accessibility were considered. Two sites were presented and analyzed in order to verify their efficiency and inclusion.
Marcos Airton Morasco Júnior   +2 more
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Fasting builds a favorable environment for effective gut microbiota modulation by microbiota-accessible carbohydrates

open access: yesBMC Microbiology
Dietary nutrients are an important determinant of gut microbial composition (Asnicar et al, Nat Med 27:321–332, 2021; Arifuzzaman. et al, Nature 611:578–584, 2022; Bolte. et al, Gut 70:1287–1298, 2021).
Kensuke Sato   +4 more
doaj   +1 more source

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