Results 121 to 130 of about 126,941 (295)

Table_1_Number of Candidate Effector Genes in Accessory Genomes Differentiates Pathogenic From Endophytic Fusarium oxysporum Strains.XLSX

, 2021
Maria E. Constantin (7108616), Like Fokkens (267437), Mara de Sain (225977), Frank L. W. Takken (7108622), Martijn Rep (258013)   +4 more
openalex   +2 more sources

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Comparative genome analyses of clinical and non-clinical Clostridioides difficile strains

Frontiers in Microbiology
The pathogenic bacterium Clostridioides difficile is a worldwide health burden with increasing morbidity, mortality and antibiotic resistances. Therefore, extensive research efforts are made to unravel its virulence and dissemination.
Miriam A. Schüler, Thomas Riedel, Thomas Riedel, Jörg Overmann, Jörg Overmann, Jörg Overmann, Rolf Daniel, Anja Poehlein   +7 more
doaj   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Core-, pan- and accessory genome analyses of Clostridium neonatale: insights into genetic diversity. [PDF]

Microb Genom, 2022
Mesa V, Monot M, Ferraris L, Popoff M, Mazuet C, Barbut F, Delannoy J, Dupuy B, Butel MJ, Aires J.   +9 more
europepmc   +1 more source

Arabidopsis TRB Proteins Form Two Closely Related Complexes to Mediate H3K4me3 Demethylation and Transcriptional Repression

Advanced Science, EarlyView.
This study reveals that Arabidopsis telomere repeat binding proteins (TRBs) form two closely related complexes. These complexes mediate H3K4me3 demethylation and transcriptional repression through a positive feedback loop and cooperate with PEAT and PRC2 complexes to regulate multiple histone modifications and gene expression across the genome ...
Qi Wang, Dan‐Yang Yuan, Yu‐Jia Lu, Xin Wang, Hao Zheng, Lin Li, She Chen, Xin‐Jian He   +7 more
wiley   +1 more source

Comparative genomics of the core and accessory genomes of 48 Sinorhizobiumstrains comprising five genospecies [PDF]

, 2013
Masayuki Sugawara, Brendan Epstein, Brian D. Badgley, Tatsuya Unno, Lei Xu, Jennifer Reese, Prasad Gyaneshwar, Roxanne Denny, Joann Mudge, Arvind K. Bharti, Andrew Farmer, Gregory D. May, Jimmy E. Woodward, Claudine Médigue, David Vallenet, Aurélie Lajus, Zoé Rouy, Betsy M. Martínez-Vaz, Peter Tiffin, Nevin D. Young, Michael J. Sadowsky   +20 more
openalex   +1 more source

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
wiley   +1 more source

Gene-gene relationships in an Escherichia coli accessory genome are linked to function and mobility. [PDF]

Microb Genom, 2021
Hall RJ, Hall RJ, Whelan FJ, Cummins EA, Connor C, McNally A, McInerney JO.   +6 more
europepmc   +1 more source

Why genes evolve faster on secondary chromosomes in bacteria [PDF]

, 2010
In bacterial genomes composed of more than one chromosome, one replicon is typically larger, harbors more essential genes than the others, and is considered primary.
Cooper, Vaughn S., Hatcher, Philip J., Vohr, Samuel H., Wrocklage, Sarah C.   +3 more
core   +1 more source