Results 141 to 150 of about 68,289 (252)

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Geographic diversity of the <i>Streptococcus equi</i> subsp. <i>equi</i> accessory genome: implications for vaccines and global surveillance. [PDF]

Front Vet Sci
He L, Khine NO, Song J, Loubière C, Butaye P.   +4 more
europepmc   +1 more source

Image_1_Number of Candidate Effector Genes in Accessory Genomes Differentiates Pathogenic From Endophytic Fusarium oxysporum Strains.JPEG

, 2021
Maria E. Constantin (7108616), Like Fokkens (267437), Mara de Sain (225977), Frank L. W. Takken (7108622), Martijn Rep (258013)   +4 more
openalex   +2 more sources

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Additional file 7 of Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06

, 2021
Julia S. Bennett, Stephen D. Bentley, Georgios S Vernikos, Michael A. Quail, Inna Cherevach, Brian R. White, Julian Parkhill, Martin Maiden   +7 more
openalex   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans. [PDF]

Genome Biol, 2019
Vasquez-Rifo A, Veksler-Lublinsky I, Cheng Z, Ausubel FM, Ambros V.   +4 more
europepmc   +1 more source

Manipulation of the infectious bronchitis coronavirus genome for vaccine development and analysis of the accessory proteins

, 2007
Dave Cavanagh, Rosa Casais, María Armesto, Teri Hodgson, Sousan Izadkhasti, Marc H. Davies, Fengsheng Lin, Ian Tarpey, Paul Britton   +8 more
openalex   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Gap-free genome assembly of FonR3 and accessory genome identification of FonR1, FonR2, FonR3.

Dilay Hazal Ayhan (22120646), Huan Wang (109286), Lili Zhang (120447), Guan Wang (109695), Shu Yi (12534147), Dian Meng (6943361), Lifang Xue (4588147), Xin Geng (571200), Zhijun Kong (22120649), Xinrui Wang (488330), Lu Wang (45927), Qingxian Yang (22120652), Xiangfeng Wang (48598), Yun Deng (67804), Xingping Zhang (8552232), Li Guo (171454)   +15 more
openalex   +1 more source