Results 191 to 200 of about 126,941 (295)

Integrative Multi‐Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer

Advanced Science, EarlyView.
Current understanding of gastric cancer immunity remains inadequate, leading to suboptimal immunotherapy outcomes. This study introduces a novel tumor immune microenvironment classification system (Inflamed, Desert, and Excluded), advancing traditional histopathological or molecular subtyping toward a functional immunological framework.
Jianchao Wang, Wenfang Zhang, Jiyang Zhang, Chenhui Zhao, Wei Zhang, Menghan Fang, Fangfang Chen, Zhida Wu, Xiaoya Xu, Ziqing Yu, Qiong Zhu, Yi Shi, Dadong Zhang, Xiaofeng Chen, Gang Chen   +14 more
wiley   +1 more source

Dual‐Pedicle Tissue‐Engineered Trachea Promotes Biomimetic Cartilaginous Framework, Vascularization, and Epithelial Lining for Long‐Segment Tracheal Reconstruction

Advanced Science, EarlyView.
Overcoming the limitations of conventional grafts, a biomimetic trachea with two independent vascular pedicles enables rapid integration and sustained patency. This approach markedly improves survival rates, restores the epithelial barrier, and promotes regenerative pathways, presenting a transformative paradigm for clinical application.
Ziming Wang, Yuming Wang, Zihao Chen, Erji Gao, Liang Guo, Juanjuan Li, Siqiang Zheng, Jiaoyu Yi, Zhe‐Sheng Chen, Bo Tao   +9 more
wiley   +1 more source

Transformation Asymmetry and the Evolution of the Bacterial Accessory Genome. [PDF]

Mol Biol Evol, 2018
Apagyi KJ, Fraser C, Croucher NJ.
europepmc   +1 more source

Gap-free genome assembly of FonR3 and accessory genome identification of FonR1, FonR2, FonR3.

Dilay Hazal Ayhan (22120646), Huan Wang (109286), Lili Zhang (120447), Guan Wang (109695), Shu Yi (12534147), Dian Meng (6943361), Lifang Xue (4588147), Xin Geng (571200), Zhijun Kong (22120649), Xinrui Wang (488330), Lu Wang (45927), Qingxian Yang (22120652), Xiangfeng Wang (48598), Yun Deng (67804), Xingping Zhang (8552232), Li Guo (171454)   +15 more
openalex   +1 more source

MOESM3 of The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans

, 2019
Alejandro Vasquez-Rifo, Isana Veksler‐Lublinsky, Zhenyu Cheng, Frederick M. Ausubel, Victor Ambros   +4 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Additional file 1 of Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06

, 2021
Julia S. Bennett, Stephen D. Bentley, Georgios S Vernikos, Michael A. Quail, Inna Cherevach, Brian R. White, Julian Parkhill, Martin Maiden   +7 more
openalex   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity

, 2016
Karin R. McDonald, Amanda J. Guise, Parham L. Pourbozorgi, Ileana M. Cristea, Virginia A. Zakian, John A. Capra, Nasim Sabouri   +6 more
openalex   +2 more sources

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid

Advanced Science, EarlyView.
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Samuel Peña‐Díaz, Yanting Jiang, Zhefei Zhang, Anders Daugberg, Pedro Ferreira, Marcos López Hernández, Chandrika Mittal, Maria Joao Ramos, Jan Skov Pedersen, Morten Kam Dahl Dueholm, Cao Qin, Huabing Wang, Daniel E. Otzen   +12 more
wiley   +1 more source