Results 181 to 190 of about 446,882 (282)

Balloon Aortic Valvuloplasty Prior to Self‐Expanding TAVI: The BAVSE‐TAVI Registry

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Direct transcatheter aortic valve implantation (TAVI) approach is feasible and safe compared to predilatation‐TAVI. Certain clinical and computerized tomography (CT)‐based characteristics might indicate the need for balloon aortic valvuloplasty (BAV) before TAVI, especially with self‐expanding valves.
Abdalazeem Ibrahem   +9 more
wiley   +1 more source

Beyond Docking: A Multitier Computational Pipeline for USP7 Inhibitor Optimization

open access: yesChemMedChem, EarlyView.
A multitier computational strategy discovers potential USP7 inhibitors using similarity‐based virtual screening, physics‐driven molecular simulations, binding free energy estimations, binary QSAR modeling, and steered molecular dynamics analysis. This integrated approach prioritizes and optimizes lead compounds with strong predicted affinity, offering ...
Ehsan Sayyah   +2 more
wiley   +1 more source

Strategies to Manage Dosing Deviations and Interruptions of Cabotegravir Long‐Acting Intramuscular Injections

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Long‐acting cabotegravir is approved for HIV treatment and prevention. To guide management of dosing deviations and interruptions, concentration‐time profiles for monthly and every 2 months regimens were simulated using a population pharmacokinetic (PPK) model.
Kelong Han   +3 more
wiley   +1 more source

Linear and Two‐Dimensional Infrared Spectroscopy of the Multifunctional Vibrational Probe, 3‐(4‐Azidophenyl) Propiolonitrile. Deperturbing a Fermi Triad by Isotopic Substitution

open access: yesChemPhysChem, Volume 26, Issue 6, March 15, 2025.
Linear infrared spectroscopy combined with isotope labeling and density functional theory unravels the origin of a Fermi triad in a multifunctional vibrational chromophore. Ultrafast 2DIR‐spectroscopy reports directly on the dynamics and the intramolecular vibrational energy flow pathways in the isotopically deperturbed system. Abstract Infrared probes
Claudia Gräve   +4 more
wiley   +1 more source

The Interplay of Public Administration and Community Resilience During the COVID‐19 Pandemic—A Rapid Scoping Review

open access: yesConflict Resolution Quarterly, EarlyView.
ABSTRACT This rapid scoping review examines the interplay between public administration and community resilience during the COVID‐19 pandemic, focusing on the type of research conducted, emerging themes in resilience studies, and key lessons learned. The findings show that research in the Global North has primarily examined resilience at the city level,
Daniela Gröschke
wiley   +1 more source

Using AI in My Disputes? Clients' Perception and Acceptance of Using AI in Mediation

open access: yesConflict Resolution Quarterly, EarlyView.
ABSTRACT This study explores how potential mediation clients perceive and accept mediators using AI in their disputes through the Unified Theory of Acceptance and Use of Technology (UTAUT). Based on 12 semi‐structured interviews, this research identifies three critical factors influencing participants' acceptance: (1) the specific tasks and processes ...
Yeju Choi
wiley   +1 more source

Itinerant curriculum theory: People's theory against the field's epistemicidal ethos

open access: yesThe Curriculum Journal, EarlyView.
Abstract The field of curriculum studies suffers from a glaring theoretical impasse. Much of this impasse has been rightly attributed to the triumphalism of the neoliberal wave that has massacred the educational hemisphere with policies and practices that reduce pedagogy to an instrumentalist praxis directly associated with the thirsty desires and ...
João M. Paraskeva
wiley   +1 more source

Rapid and Simple Dispersive Liquid–Liquid Microextraction (DLLME) Sample Preparation for Propofol Analysis in Hair, Blood, and Urine by Gas Chromatography–Mass Spectrometry

open access: yesDrug Testing and Analysis, EarlyView.
Development and validation of an extraction method based on dispersive liquid–liquid microextraction for the analysis by GC–MS of propofol in three different biological samples (blood, urine, and hair). The proposed method is very simple and rapid.
Sara Odoardi   +4 more
wiley   +1 more source

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