Results 31 to 40 of about 76,181 (245)
Gas exchanges and growth of passion fruit seedlings under salt stress and hydrogen peroxide
The semi-arid region of the Brazilian Northeast has adequate edaphoclimatic conditions for the passion fruit production, but the water used for irrigation commonly has high concentrations of salts that are harmful to the plant growth and development.
André Alisson Rodrigues da Silva +5 more
doaj +1 more source
Supplemental narrow-band 311 nm UV-B radiation was applied in order to study the effect of this specific wavelength on tobacco as a model plant. UV-B at photon fluxes varying between 2.9 and 9.9 μmol m−2 s−1 was applied to supplement 150 μmol m−2 s−1 ...
Arnold Rácz, Éva Hideg
doaj +1 more source
IntroductionPlant species often exhibit significant variation in functional traits in populations along elevational gradients to cope with varying stress conditions.
Indira Paudel +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Plastid gene expression (PGE) is crucial for plant development and acclimation to various environmental stress conditions. Members of the “mitochondrial transcription termination factor” (mTERF) family, which are present in both metazoans and plants, are
Duorong Xu +2 more
doaj +1 more source
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Photosynthetic Acclimation of Shade-Grown Soybean Seedlings to a High-Light Environment
Soybean in relay intercropping is initially exposed to a shade environment, followed by exposure to full sunlight after the harvesting of primary crops, e.g., maize.
Yahan Su +6 more
doaj +1 more source
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Plant growth strategies are adapted to resource availability in native habitat(s), and thus reflected in traits such as photosynthetic and respiratory capacities of leaves.
Jörg Kruse +6 more
doaj +1 more source

