Results 41 to 50 of about 78,895 (217)

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Genetic Variations and Differential DNA Methylation to Face Contrasted Climates in Small Ruminants: An Analysis on Traditionally-Managed Sheep and Goats

Frontiers in Genetics, 2021
The way in which living organisms mobilize a combination of long-term adaptive mechanisms and short-term phenotypic plasticity to face environmental variations is still largely unknown.
Laure Denoyelle, Laure Denoyelle, Pierre de Villemereuil, Frédéric Boyer, Meidhi Khelifi, Clément Gaffet, Florian Alberto, Badr Benjelloun, Badr Benjelloun, François Pompanon   +9 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The coordination of gene expression within photosynthesis pathway for acclimation of C4 energy crop Miscanthus lutarioriparius

Frontiers in Plant Science, 2016
As a promising candidate for the second-generation C4 energy crop, Miscanthus lutarioriparius has well acclimated to the water-limited and high-light Loess Plateau in China by improving photosynthesis rate and water use efficiency (WUE) compared to its ...
Shilai eXing, Shilai eXing, Lifang eKang, Qin eXu, Yangyang eFan, Yangyang eFan, Wei eLiu, Caiyun eZhu, Caiyun eZhu, Zhihong eSong, Zhihong eSong, Qian eWang, Qian eWang, Juan eYan, Jianqiang eLi, Tao eSang, Tao eSang   +16 more
doaj   +1 more source

The effect of fasting on the glycogen metabolism in heat-acclimated rats [PDF]

Archives of Biological Sciences, 2008
We investigated the influence of successive fasting for 24,48,72, and 96 h on some key enzymes and substrates of liver, kidney, and muscle in control and heat-acclimated (30days at 35 ± 1°C)rats.
Miova Biljana, Dinevska-Kjovkarevska Suzana, Mitev S., Dervišević Mirsada   +3 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Human Responses to Different Built Hyperthermal Environments After Short-Term Heat Acclimation

Buildings
Hyperthermal environments are encountered in many situations, and significant heat stress can exacerbate the fatigue perception of individuals and potentially threaten their safety. Heat acclimation (HA) interventions have many benefits in preventing the
Shuai Zhang, Qingqin Wang, Haizhu Zhou, Tianyang Wang, Guanguan Jia   +4 more
doaj   +1 more source

Climate Change, Bioclimatic Models and the Risk to Lichen Diversity

Diversity, 2019
This paper provides an overview of bioclimatic models applied to lichen species, supporting their potential use in this context as indicators of climate change risk.
Christopher J. Ellis
doaj   +1 more source

Artery‐on‐Chip Demonstrates Mechanical and Functional Features of Healthy and Diseased Living Smooth Muscle Tissue

Advanced Functional Materials, EarlyView.
This article details the development of an artery‐on‐chip platform for in vitro arterial disease modeling and therapeutic discovery. It describes the fabrication of a fibrin biomaterial scaffold seeded with iPSC‐derived smooth muscle and endothelial cells, mimicking native artery properties. Two genetic disease models showcase the platform's ability to
Danielle Yarbrough, Roy Chen, Katerina Katsouleas, Jaron Shoemaker, Travis Brady, Tianfang Yu, Jennifer Arthur Ataam, Connor Amelung, Lakshmi Santhanam, Ioannis Karakikes, Sharon Gerecht   +10 more
wiley   +1 more source

Shape Memory Microneedle to Prevent Risks of Reproductive Hormone Therapy by Switching Sustained to Burst Release Under a Single Transdermal Insertion

Advanced Functional Materials, EarlyView.
A shape‐memory microneedle system enables reproductive hormone therapy through a single transdermal insertion. The X‐shaped device sustains follicle‐stimulating hormone release for three days, and mild heating restores the O shape to trigger burst human chorionic gonadotropin release.
Sungwoo Cho, Hyunjae Kim, Seung Eun Yu, Sangmin Lee, Ji Youn Lee, Mi‐Lan Kang, Kang Suk Lee, Young Sik Choi, Hak‐Joon Sung   +8 more
wiley   +1 more source