Results 141 to 150 of about 128,811 (390)

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

open access: yesAdvanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li   +15 more
wiley   +1 more source

Characteristics of the Content and Variability of Dietary Fiber Components and Alkylresorcinols of Rye Grain (Secale cereale L.)

open access: yesMolecules
Rye (Secale cereale L.) is one of the most important cereals cultivated in Central and Eastern Europe, valued for its high resistance to environmental stress and high levels of bioactive compounds, such as dietary fiber (DF) and alkylresorcinols (ARR ...
Anna Fraś   +3 more
doaj   +1 more source

Metabolite Modulation in Human Plasma in the Early Phase of Acclimatization to Hypobaric Hypoxia

open access: yesScientific Reports, 2016
The exposure of healthy subjects to high altitude represents a model to explore the pathophysiology of diseases related to tissue hypoxia. We explored a plasma metabolomics approach to detect alterations induced by the exposure of subjects to high ...
Wen-Ting Liao   +11 more
semanticscholar   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

open access: yesAdvanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu   +13 more
wiley   +1 more source

A relative quantitative Methylation-Sensitive Amplified Polymorphism (MSAP) method for the analysis of abiotic stress

open access: yesBMC Plant Biology, 2017
Background We present a new methylation-sensitive amplified polymorphism (MSAP) approach for the evaluation of relative quantitative characteristics such as demethylation, de novo methylation, and preservation of methylation status of CCGG sequences ...
Piotr T. Bednarek   +2 more
doaj   +1 more source

Mesophotic coral depth acclimatization is a function of host-specific symbiont physiology

open access: yesFrontiers in Marine Science, 2015
Mesophotic coral ecosystems receive increasing attention owing to their potential as deep coral refuges in times of global environmental change. Here, the mechanisms of coral holobiont photoacclimatization over a 60 m depth gradient in the central Red ...
M. Ziegler   +3 more
semanticscholar   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang   +16 more
wiley   +1 more source

Effect of potato tuber greening on blackleg development by Dickeya solani and Pectobacterium brasiliense [PDF]

open access: yesJournal of Plant Protection Research
Potato (Solanum tuberosum) is a globally important crop, but its production is often threatened by pectinolytic bacteria of genus Pectobacterium and Dickeya, including Pectobacte­rium brasiliense (Pcb), and Dickeya solani (Ds), which cause two diseases ...
Anna Maria Grupa-Urbańska   +2 more
doaj   +1 more source

An Essay on Concept and Essencials of Acclimatization

open access: yesAnales de la Facultad de Medicina, 2014
On what conditions should acclimatization-theory be established as a science?. In analyzing the concept of acclimatization scientifically, we are several prevailing interpretation of the concept but cannot find an overal established and accepted interpretation of the concept.
openaire   +5 more sources

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