Results 281 to 290 of about 110,579 (344)

Preacclimatization and base excess rather than deficit? [PDF]

Proc Natl Acad Sci U S A
Kleinsasser A, Burtscher M.
europepmc   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

In Vitro Regeneration, Acclimatization, Phytochemical Profiling, and Antioxidant Properties of Hong Hoen Sirirugsa (<i>Globba sirirugsae</i> Saensouk & P.Saensouk). [PDF]

Plants (Basel)
Saensouk S, Sonthongphithak P, Chumroenphat T, Nonthalee S, Phrommalee P, Muangsan N, Keokene T, Saensouk P.   +7 more
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Early adaptation to high-altitude: Mood and cognitive responses at simulated 4500 m. [PDF]

Physiol Rep
Bottura RM, Bisio A, Hipolide DC.
europepmc   +1 more source

Study regarding the acclimatization and behavior of certain varieties of Asimina triloba (L.) Dunal of Romania.

, 2010
Daniela Fanuta Mihaila, I. Nicolae, Nicolae Marian   +2 more
openalex   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Differential Alteration of Gene Expression by Benzyl Adenine and <i>meta</i>-Topolin in In Vitro Apple Shoots. [PDF]

Plants (Basel)
Király A, Ambrus V, Farkas D, Abdalla N, Dobránszki J.   +4 more
europepmc   +1 more source

The Practical Application of Heat Acclimatization Induction and Intermittent Exercise-Heat Exposures in Endurance Athletes

, 2020
Yasuki Sekiguchi
openalex   +1 more source

A TtAgo‐Driven Autocatalytic Circuit with Thermal‐Enhanced Kinetics for One‐Pot Nucleic Acid Detection

Advanced Science, EarlyView.
This study proposes a universal catalytic DNA circuits termed TACTIC (Thermus thermophilus protein‐driven autocatalytic circuit) for one‐pot detection of DNA and RNA in multiple clinical samples. Integrated with machine learning, TACTIC accurately profile the distinct expression of four extracellular vesicle‐derived miRNAs across different samples and ...
Zuowei Xie, Ruijia Deng, Ben Niu, Yingjie Yang, Shuang Zhao, Hongzhao Yang, Meilin Gong, Jie Luo, Yu Tang, Jing Sheng, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source