Results 111 to 120 of about 127,272 (298)

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

The "Customer Orientation" Principle – A Prerequisite for Increased Efficiency in Tourism [PDF]

Ovidius University Annals: Economic Sciences Series, 2018
In present, the tourism sector presents on a world scale, the most dynamic field of activity,tourism products and services, are constantly demanded by an increasing number of thepopulation, tourist attractiveness being a priority for the national economy.
Ștefan (Matei) Adriana
doaj  

A GENERAL VIEW OVER THE STRUCTURAL FUNDS IN TOURISM – CASE STUDY ROMANIA - [PDF]

The major subjects of our paper are focus on the following subjects: thesupervision of the structural funds with reference to the money put at Romania’sdisposal for the development of tourism; the analysis of competitiveness in tourismthrough the 8 ...
Cristina Nistor, Lucia Sucala
core  

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Проблемні питання щодо статусу малих готелів в Україні [PDF]

, 2009
In the article the attention is focused on absence of a legal status at tourism accommodation of small forms which exist actually, but are not issued legally that considerably disturbs to development of tourist business. On the basis of studying of world
Galasyuk, S., Галасюк, С.С., Галасюк, С.С.   +2 more
core  

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

SOURCES OF RENEWABLE ENERGY AND OBTAINING THERMAL ENERGY BY DECOMPOSING VEGETABLE MATERIAL [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2019
Agritourism is one of the most suitable options available for farmers to ensure increased income. It can also serve as instrument to revive regional economy and conserve rural societies and landscapes.
George MOISE
doaj  

Diversifying Marine-Based Employment Opportunities in Peripheral Communities [PDF]

, 2009
End of project reportThis project was a development project connected to an INTERREG sub-programme called the Northern Periphery Programme (NPP). More specifically, this project was funded as an NPP Preparatory Project.
Heanue, Kevin
core  

Recent Advances and Challenges in Ammonia‐Hydrogen Energy Conversion

Advanced Science, EarlyView.
This work summarizes the latest progress of various catalytic methods in ammonia‐hydrogen energy conversion. The challenges and outlook of ammonia‐hydrogen energy conversion system are also emphasized. This work expects to build a blueprint of renewable and efficient ammonia‐hydrogen energy conversion systems under mild conditions.
Menghao Lv, Runchao Qin, Jianshuo Chen, Kaiwen Yang, Jianwei Lu, Weiwei Lei, Yifu Yu   +6 more
wiley   +1 more source