Results 61 to 70 of about 318,136 (312)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
“SUSTAINABILITY MARKETING” TO SUPPORT SUSTAINABLE TOURISM IN BALI [PDF]
Russian Journal of Agricultural and Socio-Economic Sciences, 2022 This study aims to identify and evaluate the current marketing model of the tourism industry component in Bali, analyze the positive and negative impacts of the marketing model of the current tourism industry component in Bali, and arrange possible ...
Iswara A.M.Y. +3 more
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
How millennials perceive leisure luxury hotels in a sharing economy?
Research in Hospitality Management, 2018 The introduction of both the experience and sharing economies can potentially be seen to be the start of a new type of luxury accommodation, but is that really true?
Andy Heyes, Ajay Aluri
doaj +1 more source
Features of Hotels in Spain and Their Classification [PDF]
, 2016 Розглядаються особливості готелів Іспанії як один із засобів розміщення індустрії готельного бізнесу. Охарактеризовано готельний сектор Іспанії. Визначено класифікацію засобів розміщення, їх властивості.
Mykhalchuk, T. V. +1 more
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Azores tourism product perceptions : the Influence of the country of origin [PDF]
, 2014 This study focused on the Autonomous Region of the Azores (ARA), which has some features that are considered favorable to the development of tourism and to the interest in the tourism product.
Batista, Maria da Graça Câmara +2 more
core