Results 71 to 80 of about 3,125,063 (252)

Sustainable Integrated Solid Waste Management in the TransHimalayan Accommodation Sector. [PDF]

African Journal of Hospitality, Tourism and Leisure, 2018
The purpose of this study was to characterize the waste generation profile of the tourist destinations in the Indian Trans-Himalayan region of Ladakh which are facing acute solid waste pollution. Leh town is a hub of touristic activity in Ladakh. However,
Muzafar Ahmad Wani, Zubair Ahmad Dada, Shamim Ahmad Shah   +2 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Myytävien vuodepaikkojen erillisselvitykset Tunturi-Lapissa

Matkailututkimus
  Tiivistelmä Vuodekapasiteettia käytetään yhtenä keskeisenä tilastolukuna matkailuelinkeinon seurannassa tietyllä alueella, kuten kunnassa tai matkailukeskuksessa.
Pasi Eino Satokangas
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Innovation activity in the hotel industry: evidence from Balearic Islands. [PDF]

The paper provides empirical evidence on technological activity in the Spanish service sector, in particular for the tourist accommodation in the Balearics. The study wants to fulfil the lack of analyses in the field of tourism.
Orfila-Sintes, Francina, Martínez-Ros, Ester, Crespí-Cladera, Rafel   +2 more
core  

Green Choices: Exploring Environmental Responsible Practices and Their Impact on Guest Intention in Dinokeng Accommodation Establishments [PDF]

African Journal of Hospitality, Tourism and Leisure
As the hospitality industry is expanding in developing countries, it simultaneously contributes to environmental burdens. The purpose of this article is to determine the perceptions of guests towards environmentally responsible practices (ERPs), also ...
Lulama NDZUNGU, Antoinette ROELOFFZE, Carina KLEYNHANS   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Designing a Recommendation System for Accommodation Sector of Tourism Industry [PDF]

Muṭāli̒āt-i Mudīriyyat-i Gardishgarī, 2005
Tourism industry is one of the human activities that has benefited greatly from Information Technology. This paper presents a conceptual model for accommodation in tourism industry.
mehdi kazemi, ali akbar nik nafas, mahdieh ahmad amui   +2 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source