Results 91 to 100 of about 340,845 (267)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

IMPLEMENTING ARTIFICIAL INTELLIGENCE BY SMALL ACCOUNTING FIRMS IN THE CONTEXT OF INDUSTRY 4.0: NECESSITY OR AN EXPENSIVE [PDF]

Annals of the University of Craiova: Economic Sciences Series
Large accounting firms have invested huge sums in adopting artificial intelligence to increase internal efficiency and to improve customer engagement. Achieving the potential of artificial intelligence requires, in addition to short-term expenses, long ...
Cristian Dragoș Țurcan, Andreea Gabriela Tănase, Andreea Măldăreanu, Raluca-Florentina Crețu, Viorel - Costin Banța   +4 more
doaj  

Impact of Sustainability Reporting on Financial Performance: Evidence from an Emerging Economy

Journal of Risk Analysis and Crisis Response (JRACR)
This study investigates the relationship between sustainability reporting and financial performance in Bangladesh's textile industry, focusing on economic, social, and environmental dimensions.
Sohag Ahmed Sunny, Fatema Ali Apsara
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Blockchain technology integration in tax policy: Navigating challenges and unlocking opportunities for improving the taxation of Ghana's digital economy

Scientific African
In an era marked by a profound digital transformation of economies worldwide, Ghana stands as a vivid example of a nation at the crossroads of taxation evolution.
Sampson Anomah, Boadu Ayeboafo, Maurice Aduamoah, Owusu Agyabeng   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

THE BENEFITS OF ERP AND RPA INTEGRATION IN THE CONTEXT OF INDUSTRY 4.0: EFFICIENT MASTER DATA MANAGEMENT IN THE SAP SYSTEM [PDF]

Annals of the University of Craiova: Economic Sciences Series
Given the constant development of technology, the digitization of processes is a crucial issue for economic entities that want to increase performance.
Andreea Măldăreanu, Andreea Gabriela Tănase, Cristian Dragoș Țurcan, Raluca-Florentina Crețu, Viorel - Costin Banța   +4 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ASSESSING THE DETERMINANTS OF PERFORMANCE IN WASTE RECYCLING COMPANIES IN THE CONTEXT OF INDUSTRY 4.0: AN ANALYTICAL APPROACH. [PDF]

Annals of the University of Craiova: Economic Sciences Series
This article analyzes the key factors that influence the performance of a production process in recycling plants as well as the unexpected results obtained by integrating advanced technologies.
Andreea Gabriela Tănase, Andreea Măldăreanu, Cristian Dragoș Țurcan, Raluca-Florentina Crețu, Viorel - Costin Banța   +4 more
doaj  

Management accounting practices towards financial performance in manufacturing companies, Bangladesh: Mediating role of rationalized managerial decisions

Social Sciences and Humanities Open
The aim of this study is to analyze how management accounting practices affect the financial performance of manufacturing companies in Bangladesh, taking into account the potential influence of rationalized managerial decision-making.
Fahmida Begum, Md. Musfiqur Rahman
doaj   +1 more source