Results 31 to 40 of about 503,068 (357)

Survey on the Construction Status of Forensic Virtual Autopsy Laboratory and the Applicability of Laboratory Accreditation

Fayixue Zazhi, 2023
ObjectiveTo survey the development status and actual needs of virtual autopsy technology in China and to clarify the applicability of forensic virtual autopsy laboratory accreditation.MethodsThe questionnaire was set up included three aspects： （1） the ...
GAO Jun-wei, LU Yang, LI Yan-jun, ZOU Dong-hua, HE Guang-long, WANG Yan-bin   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Disseminating good practices for patient safety: the experience of the Italian National Observatory

Epidemiology, Biostatistics and Public Health, 2016
Background: The objective of this paper is to discuss how national, collaborative programs based on the dissemination of good practices could effectively improve patient safety and be sustainable.
Barbara Labella, Patrizia Giannantoni, Vanda Raho, Quinto Tozzi, Giovanni Caracci   +4 more
doaj   +1 more source

Can Accreditation Work in Public Health? Lessons From Other Service Industries [PDF]

, 2004
Reviews the literature on the experiences and outcomes of existing accreditation programs in health and social service industries in order to derive implications about the potential benefits and costs of accreditation for public health ...
Glen P. Mays
core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Documenting Successful Experiences of Reorganizing the Hospital and Human Resource Management in an Iranian Referral Hospital During the COVID-19 Pandemic [PDF]

Journal of Evidence-Based Care
Background: Human resource provision in the COVID-19 pandemic crisis is a challenge for nursing managers. The outbreak of the COVID-19 pandemic has made a major challenge of staff for health organizations.Aim: The present study was conducted with aim to ...
Shahpar Dolati, Akram Mojarad, Mansoureh Dimeh Noghani, Marzieh Hedayat, Maliheh Morgan Torqabeh, Zohreh Sezavarmanesh, Hamidreza Jalalzaei, Mohammad-Mehdi Shahabi, Seyed Mahsan Mousavi, Zohre Pouresmail, Fatemeh Heshmati Nabavi   +10 more
doaj   +1 more source

Educating the global citizen in sustainable development: the influence of accreditation bodies on professional programmes [PDF]

, 2011
It is estimated that over 50% of UK CO2 emissions arise from the buildings and industry sector. Globally construction is estimated to be the world’s largest employer with 111 million employees. The Built Environment sector is therefore a major economic
Beacock, Peter, Perera, Srinath, Walker, Sara   +2 more
core