Results 161 to 170 of about 387,146 (299)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers   +7 more
wiley   +1 more source

Non-axisymmetric wind-accretion simulations. II. Density gradients [PDF]

open access: yesarXiv, 1999
The hydrodynamics of a variant of classical Bondi-Hoyle-Lyttleton accretion is investigated: a totally absorbing sphere moves at various Mach numbers (3 and 10) relative to a medium, which is taken to be an ideal gas having a density gradient (of 3%, 20% or 100% over one accretion radius) perpendicular to the relative motion. Similarly to the 3D models
arxiv  

Hoyle-Lyttleton Accretion in Three Dimensions

open access: yes, 2012
We investigate the stability of gravitational accretion of an ideal gas onto a compact object moving through a uniform medium at Mach 3. Previous three-dimensional simulations have shown that such accretion is not stable, and that strong rotational 'disk-
Blondin, John M., Raymer, Eric
core   +1 more source

The Emerging Paradigm of Pebble Accretion

open access: yes, 2017
Pebble accretion is the mechanism in which small particles (“pebbles”) accrete onto big bodies (planetesimals or planetary embryos) in gas-rich environments.
C. Ormel
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Spin Evolution of Neutron Stars

open access: yesGalaxies
In this paper we review the basics of magneto-rotational properties of neutron stars focusing on spin-up/spin-down behavior at different evolutionary stages.
Pavel Abolmasov   +2 more
doaj   +1 more source

Stable accretion from a cold disc in highly magnetized neutron stars

open access: yes, 2017
The aim of this paper is to investigate the transition of a strongly magnetized neutron star into the accretion regime with very low accretion rate. For this purpose we monitored the Be-transient X-ray pulsar GRO J1008-57 throughout a full orbital cycle.
Abolmasov, P. K.   +6 more
core   +2 more sources

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