Results 181 to 190 of about 26,473 (258)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 3: Impacts on Growth, Neurodevelopment & Nutrition. [PDF]

Children (Basel)
Plessas-Azurduy P, Garfinkle J, Beltempo M, Porraccio C, Lapointe A, Wazneh L, Wutthigate P, Spénard S, Sbrocchi AM, Racine MB, Mawad W, Cavallé-Garrido T, Shalish W, Sant'Anna G, Altit G.   +14 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From Growth Trajectory to Functional Decline: Age-Contextualized Nutritional Strategies for Muscle Vulnerability. A Narrative Review. [PDF]

Nutrients
Malaguarnera L, Sortino V, Surdo S, Piro S.   +3 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Direct evidence for magnetohydrodynamic disk winds driving rotating outflows in protostar HOPS 358. [PDF]

Nat Commun
Kim CH, Lee JE, Johnstone D, Herczeg GJ, Lee CF, Francis L, Sheehan PD.   +6 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Coral growth, retraction, defense, and regenerative strategies revealed by live microCT. [PDF]

Sci Adv
Araslanova K, Kaiser M, Fetisov A, Gavrik D, Zikmund T, Abed-Navandi D, Katovský K, Kaiser J, Adameyko I.   +8 more
europepmc   +1 more source

Planetesimal Accretion under a Realistic Accretion Condition

Planetesimal Accretion under a Realistic Accretion Condition
学位の種別: 課程博士 審査委員会委員 : （主査）東京大学准教授 藤井 通子, （副査）東京大学教授 相川 裕理, 東北大学教授 田中 秀和, 神戸大学教授 大槻 圭史, 東京大学教授 深川 ...
openaire  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source