Results 201 to 210 of about 26,473 (258)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The connection between the fastest astrophysical jets and the spin axis of their black hole. [PDF]

Nat Astron
Fender RP, Motta SE.
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Arsenic enrichment patterns are defined by microbialite morphology, fabric, and accretion mechanism. [PDF]

Nat Commun
Pollier CGL, Reid RP, Suosaari EP, Vitek BE, Dupraz C, Oehlert AM.   +5 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Skeletal muscle memory: implications for sports, aging and nutrition. [PDF]

Front Nutr
Pérez-Castillo ÍM, Ruiz-Caride SR, Rueda R, López-Chicharro J, Segura-Ortiz F, Bouzamondo H.   +5 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Nitric oxide can enhance secondary aerosol precursor formation from aromatic carbonyls. [PDF]

Nat Commun
Barua S, Kumar A, Seal P, Bezaatpour M, Jha S, Myllys N, Iyer S, Rissanen M.   +7 more
europepmc   +1 more source

Whence the demise and fall of the RNA World?

Medvegy A, Abramov O, Kremer B, Mojzsis S.   +3 more
europepmc   +1 more source

Quantifying riverbank and soil erosion risks in the upper Ghaghara river basin and their implications for flood management. [PDF]

Sci Rep
Pandey SK, Singh S, Supe H, Calay RK, Avtar R.   +4 more
europepmc   +1 more source