Results 161 to 170 of about 118,894 (281)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Development and external-validation of a mechanistic dynamic nutrient-partitioning model for predicting growth and body composition in male guinea pigs (Cavia porcellus) of the Peru genotype. [PDF]

Vet World
Rosero-Noguera JR, Carvajal J, Posada-Ochoa SL.   +2 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Seabirds and native vegetation drive ecosystem processes that support atoll island resilience. [PDF]

Sci Adv
Graham NAJ, Benkwitt CE, Lange ID, Perry CT, Thomson ER, Wedding LM, Dunn RE, Steibl S, Stuart CE, Jeannot LL, Appoo J, Rodriguez Fillol J, Stuhr M, Palola P, Carr P, DeVore JL, Ducatez S, Zora A, Hastings AK, Barroso SF, Evans S, Schulze M, Cotton E, Reddington H, Malhi Y.   +24 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Rapid quasi-periodic reconfiguration of the accretion column in pulsar 1A 0535+262. [PDF]

Nat Commun
Kong L, Dai X, Santangelo A, Ji L, Suleimanov VF, Mushtukov AA, Ducci L, Zhang S, Shui Q, Zhang SN, Feng H, Tsygankov SS, Liu H, Wang P, Liu Q.   +14 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Solving the cooling flow problem with combined jet-wind AGN feedback. [PDF]

Sci Adv
He A, Yuan F, Ji S, Guo M, Li Y, Xu H, Sun M, Xia H, Zhao Y.   +8 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Paleomagnetic evidence for a nebular magnetic field from calcium-aluminum-rich inclusions. [PDF]

Proc Natl Acad Sci U S A
Borlina CS, Weiss BP, Bai XN, Tung PY, Harrison RJ, Mansbach EN, Chatterjee N, Tissot FLH, McKeegan KD.   +8 more
europepmc   +1 more source