Results 81 to 90 of about 40,120 (302)
FEBS Open Bio, EarlyView.This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili +2 more
wiley +1 more source
, 2015 A key component of explaining the array of galaxies observed in the Universe is the feedback of active galactic nuclei, each powered by a massive black hole's accretion disc. For accretion to occur, angular momentum must be lost by that which is accreted.
Stevens, Adam R. H.
core +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Radiative properties and QPOs around charged black hole in Kalb–Ramond gravity
European Physical Journal C: Particles and FieldsStudies of accretion disc luminosities and quasiperiodic oscillations around black holes may help us understand the gravitational properties of black hole spacetime.
Shokhzod Jumaniyozov +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
The Role of Gravitational Instabilities in the Feeding of Supermassive Black Holes
Advances in Astronomy, 2012 I review the recent progresses that have been obtained, especially through the use of high-resolution numerical simulations, on the dynamics of self-gravitating accretion discs.
Giuseppe Lodato
doaj +1 more source
ON OBSERVATIONAL PHENOMENA RELATED TO KERR SUPERSPINARS
Acta Polytechnica, 2014 We investigate possible signatures of a Kerr naked singularity (superspinar) in various observational phenomena. It has been shown that Kerr naked singularities (superspinars) have to be efficiently converted to a black hole due to accretion from ...
Zdenek Stuchlik, Jan Schee
doaj +1 more source
On the driver of relativistic effects strength in Seyfert galaxies
, 2011 Spectroscopy of X-ray emission lines emitted in accretion discs around supermassive black holes is one of the most powerful probes of the accretion flow physics and geometry, while also providing in principle observational constraints on the black hole ...
Bianchi, S. +4 more
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source