Results 21 to 30 of about 380 (216)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato +2 morewiley +1 more sourceLBO’s & Strategic M&A: Financial Analysis of Yahoo!, inc. in 2008
, 2022 As a Finance major at the University of Mississippi, I have had the opportunity to learn about a variety of different aspects of corporate finance. This ultimately led to me pursuing a career in the field of investment banking. I came into my senior year Gilliland, Brandoncore Submillimeter Continuum Variability in Planck Galactic Cold Clumps [PDF]
, 2019 In the early stages of star formation, a protostar is deeply embedded in an optically thick envelope such that it is not directly observable. Variations in the protostellar accretion rate, however, will cause luminosity changes that are reprocessed by ...Mairs, Steve, Lee, CW, Lee, Chang Won, Kang, S-J, Liu, Tie, T., Koch, Patrick, Choi, Minho, Yoo, H, Eden, David, Johnstone, D, Zhang, CP, Lee, Jeong-Eun, Zhang, C-P, Fuller, Gary, Montillaud, Julien, Zhang, Chuan-Peng, Lee, J-E, Stamatellos, D, Sanhueza, Patricio, Rawlings, Jonathan, Kang, Sung-ju, Kim, G, Kim, Kee Tae, Lee, Jeong Eun, Park, Geumsook, Kang, Miju, Kim, KT, Fuller, Gary A.; id_orcid, Soam, A, Eden, DJ, Liu, T, Kwon, W, Kwon, Woojin, Lee, JE, Liu, Tie,, Sanhueza, P, Koch, PM, Kang, SJ, Montillaud, J, Kim, Gwanjeong, Fuller, GA, Zhang, Chuan Peng, Choi, M, Eden, D, Koch, Patrick M., Stamatellos, Dimitris, Juvela, M, Juvela, Mika, Rawlings, J, Kim, Kee-Tae, Kim, K-T, Johnstone, Doug, Liu, Tie, Fuller, Gary A., Mairs, S, Park, G, Soam, Archana, Kang, Sung ju, Yoo, Hyunju, Kang, M +59 morecore +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more sourceA search for pulsars around Sgr A* in the first Event Horizon Telescope data set [PDF]
, 2023 In 2017 the Event Horizon Telescope (EHT) observed the supermassive black hole at the center of the Milky Way,
Sagittarius A* (Sgr A*), at a frequency of 228.1 GHz (λ = 1.3 mm).Broguiere, Dominique, Schuster, Karl-Friedrich, Blundell, Raymond, Nakamura, Masanori, Chatterjee, Shami, Van Rossum, Daniel R., Wex, Norbert, Cruz-Osorio, Alejandro, Ransom, Scott M., Cho, Ilje, Deane, Roger, Jorstad, Svetlana, Satapathy, Kaushik, Crawford, Thomas M., Paraschos, Georgios Filippos, Sasada, Mahito, Bronzwaer, Thomas, Moran, James M., Oyama, Tomoaki, Medeiros, Lia, Sánchez-Portal, Miguel, Wong, George N., Levis, Aviad, Younsi, Ziri, Abbate, Federico, Mus, Alejandro, Lindahl, Greg, Lonsdale, Colin J., Lee, Sang-Sung, Lisakov, Mikhail, Hesper, Ronald, Bintley, Dan, Garcia, Roberto, Alberdi, Antxon, Cui, Yuzhu, Kino, Motoki, Narayanan, Gopal, Fraga-Encinas, Raquel, Young, Andre, Gurwell, Mark, Wondrak, Michael F., Kuo, Cheng-Yu, Boyce, Hope, Foschi, Marianna, Hecht, Michael H., Yfantis, Aristomenis, Marti-Vidal, Ivan, Mizuno, Yosuke, Conroy, Nicholas S., Small, Des, Dzib, Sergio A., Lauer, Tod R., Ros, Eduardo, Chang, Dominic O., Roy, Alan L., Crew, Geoffrey, B., Park, Jongho, Shen, Zhiqiang, Pötzl, Felix M., Rao, Ramprasad, Fish, Vincent L., Zhao, Guang-Yao, Patel, Nimesh, Nowak, Michael A., Wongphechauxsorn, Jompoj, Pen, Ue-Li, Keating, Garrett K., Barrett, John, Bower, Geoffrey C., Kofuji, Yutaro, Goddi, Ciriaco, Zhang, Shuo, Pesce, Dominic W., Noutsos, Aristeidis, Ramakrishnan, Venkatessh, Nagai, Hiroshi, Gomez, Jose L., Lo, Wen-Ping, Carlstrom, John E., Gold, Roman, Davelaar, Jordy, Leung, Po Kin, Weintroub, Jonathan, Gammie, Charles F., Azulay, Rebecca, Ball, David, Haworth, Kari, Doeleman, Sheperd S., Emami, Razieh, Yuan, Ye-Fei, Bouman, Katherine L., Friberg, Per, Wiik, Kaj, Wagner, Jan, Lico, Rocco, Wharton, Robert, Christian, Pierre, Jeter, Britton, van Langevelde, Huib Jan, Ward-Thompson, Derek, Balokovic, Mislav, Hada, Kazuhiro, Chael, Andrew, Chen (陈永军), Yongjun, Psaltis, Dimitrios, Ripperda, Bart, Nagar, Neil M., Lindqvist, Michael, Van Bemmel, Ilse, Schloerb, F. Peter, Yadlapalli, Nitika, Salamanca, Juan J., Koyama, Shoko, Okino, Hiroki, Prather, Ben, Sanchez-Arguelles, David, Dhruv, Vedant, Gentaz, Olivier, Zhao, Shan-Shan, Roelofs, Freek, Anantua, Richard, Freeman, William T., Rogers, Alan, Trippe, Sascha, Alef, Walter, La Bella, Noemi, Marrone, Daniel P., Jannuzi, Buell T., Witzel, Gunther, Johnson, Michael D., Yuan, Feng, Paubert, Gabriel, Baczko, Anne-Kathrin, Krichbaum, Thomas P., Young, Ken, De Laurentis, Mariafelicia, Parsons, Harriet, Cordes, James M., Falcke, Heino, Shao, Lijing, Desvignes, Gregory, Heumann, Dirk, Kim, Jongsoo, Kramer, Michael, Georgiev, Boris, Michalik, Daniel, Neri, Roberto, Souccar, Kamal, Sohn, Bong Won, Markoff, Sera, Turk, Matthew, Plambeck, Richard, Navarro, Santiago, Dempsey, Jessica, Lobanov, Andrei P., Dougal, Sean, Castillo, Manuel, Porth, Oliver, Loinard, Laurent, Huang (黄磊), Lei, Fromm, Christian M., Karuppusamy, Ramesh, Rawlings, Mark G., Titus, Michael, Rezzolla, Luciano, Toscano, Teresa, Ni, Chunchong, Farah, Joseph, Baubock, Michi, Cheng, Xiaopeng, Honma, Mareki, Vos, Jesse, Inoue, Makoto, Savolainen, Tuomas, Zensus, J. Anton, Myserlis, Ioannis, Impellizzeri, C. M. Violette, PopStefanija, Aleksandar, Marscher, Alan P., Matsushita, Satoki, Eatough, Ralph P., Piétu, Vincent, Yamaguchi, Paul, Galison, Peter, Olivares, Hector, John, David, Kim, Dong-Jin, Marchili, Nicola, Muller, Cornelia, Jiménez-Rosales, Alejandra, Sanchez, Salvador, Kawashima, Tomohisa, Traianou, Efthalia, Byun, Do-Young, Conway, John E., Kettenis, Mark, Ho (何子山), Luis C., Palumbo, Daniel C. M., Raymond, Alexander W., Tilanus, Remo P. J., Bustamante, Sandra, Brinkerink, Christiaan D., Liuzzo, Elisabetta, Bremer, Michael, SooHoo, Jason, Hughes, David H., Dahale, Rohan, Rottmann, Helge, Ikeda, Shiro, Akiyama, Kazunori, Joshi, Abhishek, V., Ricarte, Angelo, Benson, Bradford A., Preciado-López, Jorge A., James, David J., Janssen, Michael, Jung, Taehyun, Broderick, Avery E., Fomalont, Ed, Gu (顾敏峰), Minfeng, Kocherlakota, Prashant, Bach, Uwe, Asada, Keiichi, Huang, Chih-Wei L., Özel, Feryal, Muller, Hendrik, Liu, Jun, Ruszczyk, Chet, Trent, Tyler, Wielgus, Maciek, Yu, Wei, Pu, Hung-Yi, Karami, Mansour, Wardle, John, Lee, Daeyoung, Li (李志远), Zhiyuan, Algaba, Juan Carlos, Mizuno, Izumi, Natarajan, Iniyan, Britzen, Silke, Moscibrodzka, Monika, Oh, Junghwan, Haggard, Daryl, Narayan, Ramesh, Ortiz-Leon, Gisela N., Nathanail, Antonios, Dexter, Jason, Gomez-Ruiz, Arturo I., Liu, Kuo, Sun, He, Brissenden, Roger, Chatterjee, Koushik, Fuentes, Antonio, Menten, Karl M., Nadolski, Andrew, Jiang, Wu, Schonfeld, Jonathan, Kramer, Carsten, Tetarenko, Alexandra J., Kim, Junhan, Musoke, Gibwa, Roshanineshat, Arash, Blackburn, Lindy, Ceccobello, Chiara, Herrera-Aguilar, Alfredo, Ho, Paul, Neilsen, Joey, Moriyama, Kotaro, Wu, Qingwen, Lu, Ru-Sen, Romero-Canizales, Cristina, Chan, Chi-kwan, Chen, Ming-Tang, Ruiz, Ignacio, Rygl, Kazi L. J., Yoon, Doosoo, Ford, H. Alyson, Torne, Pablo, Koay, Jun Yi, Issaoun, Sara, Kim, Jae-Young, Matthews, Lynn D., Tiede, Paul +282 morecore +1 more sourceEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceHeterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig +10 morewiley +1 more sourceMITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson +13 morewiley +1 more source
