Results 31 to 40 of about 380 (216)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

First Sagittarius A Event Horizon Telescope results. IV. Variability, morphology, and black hole mass [PDF]

, 2022
REST OF AUTHORS : Dempsey, Jessica; Desvignes, Gregory; Dexter, Jason; Dhruv, Vedant; Doeleman, Sheperd S.; Dougal, Sean; Dzib, Sergio A.; Eatough, Ralph P.; Emami, Razieh; Falcke, Heino; Farah, Joseph; Fish, Vincent L.; Fomalont, Ed; Ford, H.
Britzen, Silke, Baczko, Anne-Kathrin, Alberdi, Antxon, Broguiere, Dominique, Blundell, Raymond, Cui, Yuzhu, De Laurentis, Mariafelicia, Cordes, James M., Akiyama, Kazunori, Cruz-Osorio, Alejandro, Cho, Ilje, Deane, Roger, Crawford, Thomas M., Benson, Bradford A., Boyce, Hope, Carlstrom, John E., Brissenden, Roger, Bronzwaer, Thomas, Chatterjee, Koushik, Broderick, Avery E., Bach, Uwe, Davelaar, Jordy, Asada, Keiichi, Conroy, Nicholas S., Byun, Do-Young, Conway, John E., Azulay, Rebecca, Ball, David, Crew, Geoffrey B., Blackburn, Lindy, Ceccobello, Chiara, Anantua, Richard, Chatterjee, Shamiuntranslated, Bustamante, Sandra, Chan, Chi-kwan, Alef, Walter, Baubock, Michi, Chen, Ming-Tang, Cheng, Xiaopeng, Brinkerink, Christiaan D., Christian, Pierre, Balokovic, Mislav, Barrett, John, Bremer, Michael, Algaba, Juan Carlos, Bower, Geoffrey C., Chael, Andrew, Chen (陈永军), Yongjun   +47 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Apple Inc’s acquisition of Lions Gate Entertainment Corp. [PDF]

, 2022
This dissertation intends to analyze the potential acquisition of Lions Gate Entertainment Corporation by Apple Inc. Apple is putting a notable amount of resources into competing in the entertainment market, and this acquisition would significantly ...
Jakobsen, Ole Christian Raaen
core  

First Sagittarius A* Event Horizon Telescope Results. V. Testing Astrophysical Models of the Galactic Center Black Hole

, 2022
Funding Information: The Event Horizon Telescope Collaboration thanks the following organizations and programs: the Academia Sinica; the Academy of Finland (projects 274477, 284495, 312496, 315721); the Agencia Nacional de Investigación y Desarrollo ...
, Event Horizon Telescope Collaborat, Savolainen, Tuomas, Ramakrishnan, Venkatessh   +2 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Faktor PAD Memediasi Pengaruh Belanja Modal Pada Pertumbuhan Ekonomi Daerah Di Kabupaten/Kota Se-Bakorwil 1 Madiun

This studi aims to test the influence of capital spending on economic accretion mediated by Original Local Government Revenue (PAD) in districts/cities in Bakorwil 1 Madiun in 2012 - 2022.
Rendah Istiqaroh, Choirum, Wibisono, Nurharibnu, Mulyati, Tatik, Iswati, Retno   +3 more
core   +1 more source

First Sagittarius A* Event Horizon Telescope Results. I. The Shadow of the Supermassive Black Hole in the Center of the Milky Way

, 2022
Funding Information: The Event Horizon Telescope Collaboration thanks the following organizations and programs: the Academia Sinica; the Academy of Finland (projects 274477, 284495, 312496, 315721); the Agencia Nacional de Investigación y Desarrollo ...
, Event Horizon Telescope Collaborat, Savolainen, Tuomas, Ramakrishnan, Venkatessh   +2 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source