Results 201 to 210 of about 280,695 (304)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Gender differences in the association between adverse childhood experiences and impulsivity in Saudi Arabian adults: A cross-sectional study. [PDF]

PLoS One
Alghamdi SA.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

EL PREMIO DE TRADUCCIÓN ESTHER BENÍTEZ.

Hermeneus, 2011
María Teresa GALLEGO URRUTIA, Carmen FRANCÍ VENTOSA   +1 more
doaj  

Angiotensin-converting enzyme signalling in human preadipocytes and adipocytes

Open Life Sciences, 2006
Böttcher Andreas, Böttcher Alfred, Schmitz Gerd, Schling Petra   +3 more
doaj   +1 more source

Engineered tRNA reduces vision loss in a mouse model of Leber congenital amaurosis. [PDF]

Signal Transduct Target Ther
Shahi PK, Akyuz E, Gissot L, Al Saneh A, Pillala SK, Sinha D, Hanstad GM, Kabra M, Fernandez Zepeda MA, Gamm DM, Young SM, Ahern CA, Pattnaik BR.   +12 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Semi-supervised medical image captioning via anatomical collaborative evidence network. [PDF]

Front Med (Lausanne)
Zhou S, Liu Q, Cai L, Lu K, Qiao L, Xu N, Wu Y, Xu Y, Li J.   +8 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

AI-empowered clinical evidence for integrated Chinese-Western medicine: Introduction to the ACE-iMed series and platform dissemination. [PDF]

Integr Med Res
Yu X, Ma Y, Luo X, Chen Y, Bian Z.
europepmc   +1 more source