Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Exploring bioactive peptides from Andean grains and their potential applications: a review. [PDF]
Damiano-Vásquez B +2 more
europepmc +1 more source
Neurophysiological Evidence of Enhanced Cognitive Control Following Auditory Control Enhancement (ACE) Therapy: A Pilot RCT in Schizophrenia-Spectrum Disorders with Persistent Auditory Hallucinations. [PDF]
Coffman BA +9 more
europepmc +1 more source
Exploratory screening of wild-game tissues in Japan toward value-added utilization: estimated soluble protein/peptide yields and DPPH radical-scavenging and ACE-inhibitory activities after in vitro digestion. [PDF]
Ogi H +4 more
europepmc +1 more source
Structure-function insights into the digestive fate of angiotensin-converting enzyme-inhibitory peptides from microwave-treated corn gluten meal. [PDF]
Hamzeh A +7 more
europepmc +1 more source
Myocardial perfusion and ACE inhibition.
openaire +1 more source
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ACE inhibition and atherogenesis
Canadian Journal of Physiology and Pharmacology, 2002Recent clinical studies such as HOPE, SECURE, and APRES show that angiotensin-converting enzyme (ACE) inhibitors like ramipril improve the prognosis of patients with a high risk of atherothrombotic cardiovascular events. Atherosclerosis, as a chronic inflammatory condition of the vascular system, can turn into an acute clinical event through the ...
B A, Schölkens, W, Landgraf
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Cardiac Effects of ACE Inhibition
Journal of Cardiovascular Pharmacology, 1993Hypertension frequently is associated with a number of changes in heart structure and function, such as left ventricular hypertrophy, disturbed diastolic function, and subnormal stroke volume during exercise. Most of these changes probably are related to myocardial fibrosis.
P, Lund-Johansen, P, Omvik
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Background The mechanisms by which ACE inhibitors produce a sustained clinical benefit are not entirely clear but may involve the sympathetic nervous system. We compared the effect of local brachial artery infusions of an ACE inhibitor (perindoprilat) with the effect of placebo (0.9% NaCl) on endogenously mediated (lower body ...
D, Lyons, S, Roy, S, O'Byrne, C G, Swift
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