Results 251 to 260 of about 69,918 (298)
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Evidence-Based Medicine and ACE Inhibition
Journal of Cardiovascular Pharmacology, 1998The use of angiotensin-converting enzyme (ACE) inhibitors has been generally beneficial in the treatment of many clinical conditions characterized by a significant degree of cardiovascular and renal involvement. Most of the available data on the benefits of ACE inhibitors have come from well-conducted large clinical trials that have provided much ...
C, Borghi, E, Ambrosioni
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ACE Inhibition and the Vascular Intima in Hypertension
Journal of Cardiovascular Pharmacology, 1993Both the function and the morphology of the vascular intima are altered during hypertension. In spontaneously hypertensive rats, endothelium-dependent relaxation is decreased, and the subendothelium becomes infiltrated with monocyte macrophages. It is not known if these two features are secondary to high blood pressure and what their consequences are ...
M, Clozel, H, Kuhn, H R, Baumgartner
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Journal of Cardiovascular Pharmacology, 1990
Results of uncontrolled studies suggest that the duration of action of an ACE inhibitor may be an important determinant of renal impairment when using these agents to treat patients with heart failure. To determine whether there is experimental evidence for this hypothesis, we compared the effects of intermittent (captopril, 25 mg i.v.
M A, Fitzpatrick +6 more
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Results of uncontrolled studies suggest that the duration of action of an ACE inhibitor may be an important determinant of renal impairment when using these agents to treat patients with heart failure. To determine whether there is experimental evidence for this hypothesis, we compared the effects of intermittent (captopril, 25 mg i.v.
M A, Fitzpatrick +6 more
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ACE Inhibition in Hypertension
American Journal of Cardiovascular Drugs, 2007Ongoing developments in our understanding of cardiovascular disease, together with the introduction of new drugs to treat these conditions, has led to much debate over the optimal management of hypertension. The ALLHAT study showed no major differences in cardiovascular outcome among three major classes of antihypertensive drugs.
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The Effects of ACE Inhibition on Progression of Atherosclerosis
Journal of Cardiovascular Pharmacology, 1993Angiotensin-converting enzyme inhibitors have been extensively studied and established in the treatment of hypertension, heart failure, and ventricular dysfunction. They have various cardiac and vascular protective effects, but the relevant mechanisms of action in these areas remain to be fully understood.
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ACE inhibition in the tissues.
Clinical physiology and biochemistry, 1993The discovery of the components of the renin angiotensin system (RAS) in various tissues gave rise to the idea that functional "tissue" renin-angiotensin systems exist that are more or less independent of the hormonal RAS. Further support to this notion came from the recent demonstration of the mRNA for the protein components of the RAS in a number of ...
T, Unger, P, Gohlke
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Triple ACE-ECE-NEP Inhibition in Heart Failure: A Comparison With ACE and Dual ECE-NEP Inhibition
Journal of Cardiovascular Pharmacology, 2005Abstract: Mortality remains high in chronic heart failure (CHF) because under ACE inhibitor treatment other neurohumoral systems remain/become (de)activated, such as the endothelin and atrial natriuretic peptide pathways.
Virginie, Mellin +6 more
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Cardiovascular Drugs and Therapy, 2001
Aldosterone exerts pro-fibrotic effects, acting via mineralo-corticoid reeptors in cardiovascular tissues. Aldosterone antagonism in combination with ACE inhibition may better protect against untoward effects of aldosterone than ACE inhibition alone.In a double blind, randomised study the tolerability and efficacy of canreonate (25 mg/day) plus ...
P, Di Pasquale +5 more
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Aldosterone exerts pro-fibrotic effects, acting via mineralo-corticoid reeptors in cardiovascular tissues. Aldosterone antagonism in combination with ACE inhibition may better protect against untoward effects of aldosterone than ACE inhibition alone.In a double blind, randomised study the tolerability and efficacy of canreonate (25 mg/day) plus ...
P, Di Pasquale +5 more
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Effects of ACE inhibition on the heart.
Journal of human hypertension, 1995Inhibition of the angiotensin converting enzyme (ACE) results in suppression of the formation of angiotensin II and delay of the degradation of bradykinin. Hence, the pharmacological effects of ACE inhibitors are attributable to both of these mechanisms.
I, Gavras, A, Manolis, H, Gavras
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Present and future of ACE inhibition
Trends in Pharmacological Sciences, 2002ACE Inhibitorsedited by P. D'Orleans-Juste and G.E. Plante, Birkhauser Verlag, 2001. Euro119 (hardback) (x + 184 pages) ISBN 376435982XToday, blockers of the renin–angiotensin system are standard therapy for essential hypertension and congestive heart failure, and represent an important step in the management of patients with diabetic and non-diabetic ...
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