Results 251 to 260 of about 140,143 (309)

ACE inhibition and atherogenesis

Canadian Journal of Physiology and Pharmacology, 2002
Recent clinical studies such as HOPE, SECURE, and APRES show that angiotensin-converting enzyme (ACE) inhibitors like ramipril improve the prognosis of patients with a high risk of atherothrombotic cardiovascular events. Atherosclerosis, as a chronic inflammatory condition of the vascular system, can turn into an acute clinical event through the ...
B A, Schölkens, W, Landgraf
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Cardiac Effects of ACE Inhibition

Journal of Cardiovascular Pharmacology, 1993
Hypertension frequently is associated with a number of changes in heart structure and function, such as left ventricular hypertrophy, disturbed diastolic function, and subnormal stroke volume during exercise. Most of these changes probably are related to myocardial fibrosis.
P, Lund-Johansen, P, Omvik
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Clinical Pharmacology of ACE Inhibition

Cardiology, 1989
The radioimmunological determinations of immunoreactive 'angiotensin II' do not truly reflect angiotensin-(1-8)octapeptide levels, and thus cannot provide an accurate reflection of the efficacy of angiotensin-converting enzyme (ACE) inhibition. Elaborate methods are necessary to measure specifically the octapeptide angiotensin II.
Nussberger J, Waeber B, Brunner HR
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ACE Inhibition

Circulation, 1997
Background The mechanisms by which ACE inhibitors produce a sustained clinical benefit are not entirely clear but may involve the sympathetic nervous system. We compared the effect of local brachial artery infusions of an ACE inhibitor (perindoprilat) with the effect of placebo (0.9% NaCl) on endogenously mediated (lower body ...
D, Lyons, S, Roy, S, O'Byrne, C G, Swift
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Vascular Effects of ACE Inhibition by Perindopril

Drugs, 1990
Hypertension and ageing are associated with decreased arterial compliance, increased thickening of the arterial wall, hypertrophy of arterial smooth muscle cells and an increase in the collagen content of the arterial wall. Increased blood pressure has been implicated as a causative factor in such adaptive vascular alterations, however, other factors ...
J B, Michel, B I, Levy
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Evidence-Based Medicine and ACE Inhibition

Journal of Cardiovascular Pharmacology, 1998
The use of angiotensin-converting enzyme (ACE) inhibitors has been generally beneficial in the treatment of many clinical conditions characterized by a significant degree of cardiovascular and renal involvement. Most of the available data on the benefits of ACE inhibitors have come from well-conducted large clinical trials that have provided much ...
C, Borghi, E, Ambrosioni
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ACE Inhibition and the Vascular Intima in Hypertension

Journal of Cardiovascular Pharmacology, 1993
Both the function and the morphology of the vascular intima are altered during hypertension. In spontaneously hypertensive rats, endothelium-dependent relaxation is decreased, and the subendothelium becomes infiltrated with monocyte macrophages. It is not known if these two features are secondary to high blood pressure and what their consequences are ...
M, Clozel, H, Kuhn, H R, Baumgartner
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