Results 1 to 10 of about 6,534 (185)

Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor. [PDF]

FEBS J, 2016
Several soil‐derived Actinobacteria produce secondary metabolites that are proven specific and potent inhibitors of the human angiotensin‐I‐converting enzyme (ACE), a key target for the modulation of hypertension through its role in the renin–angiotensin–aldosterone system.
Masuyer G, Cozier GE, Kramer GJ, Bachmann BO, Acharya KR.   +4 more
europepmc   +4 more sources

Association between the polymorphisms of angiotensin converting enzyme (Peptidyl-Dipeptidase A) INDEL mutation (I/D) and Angiotensin II type I receptor (A1166C) and breast cancer among post menopausal Egyptian females

Alexandria Journal of Medicine, 2014
Renin angiotensin system (RAS) is involved in the regulation of cardiovascular homeostasis. Angiotensin (Ang II) is converted from angiotensin I via angiotensin converting enzyme (ACE). Ang II exerts its effects by binding to two types of receptors; AT1R
Rania Mohamed El Sharkawy, Ahmed Mohamed Zaki, Amal Abd El Fattah Kamel, Rania Nabil Bedair, Ahmed Saad Ahmed   +4 more
exaly   +3 more sources

The metabolism of neuropeptides. Neurokinin A (substance K) is a substrate for endopeptidase-24.11 but not for peptidyl dipeptidase A (angiotensin-converting enzyme) [PDF]

Biochemical Journal, 1985
Both endopeptidase-24.11 and peptidyl dipeptidase A have previously been shown to hydrolyse the neuropeptide substance P. The structurally related peptide neurokinin A is also shown to be hydrolysed by pig kidney endopeptidase-24.11. The identified products indicated hydrolysis at two sites, Ser5-Phe6 and Gly8-Leu9, consistent with the known ...
Nigel M Hooper, A J Kenny, Anthony J Turner   +2 more
exaly   +3 more sources

Identification and properties of a peptidyl dipeptidase in the housefly, Musca domestica, that resembles mammalian angiotensin-converting enzyme. [PDF]

Biochem J, 1994
[D-Ala2,Leu5]Enkephalin was readily metabolized by membranes (40,000 g pellet) prepared from heads of the housefly, Musca domestica, with Gly3-Phe4 being the major site of cleavage. This hydrolysis was only partially inhibited (40%) by 10 microM phosphoramidon, an inhibitor of endopeptidase-24.11, but was almost totally abolished in the presence of a ...
Lamango NS, Isaac RE.
europepmc   +4 more sources

Levels of angiotensin-converting enzyme 1 and 2 in serum and urine of children with Sickle Cell Disease

Brazilian Journal of Nephrology, 2021
Introduction: Sickle cell nephropathy begins in childhood and presents early increases in glomerular filtration, which, over the long term, can lead to chronic renal failure.
Ho Chi Hsien, Dulce Elena Casarini, João Tomas de Abreu Carvalhaes, Fernanda Aparecida Ronchi, Lilian Caroline Gonçalves de Oliveira, Josefina Aparecida Pellegrini Braga   +5 more
doaj   +2 more sources

Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Renin⁃angiotensin system (RAS) plays an important role in maintaining cardiovascular homeostasis, water and electrolyte balance in the body, and angiotensin converting enzyme Ⅱ (ACE2) and its axis of action angiotensin⁃(1⁃7) [Ang⁃(1⁃7)] and Mas receptor (
LIANG He , LIN Jian⁃wen , MO Ming, XIE Lu⁃shuang , DU Shi⁃wei , LIU Yi   +5 more
doaj   +1 more source

Aristolochic acid induces chronic kidney disease in ace knockout mice

International Journal of Preventive Medicine, 2021
Background: Aristolochic acid I (AAI) is an extract from Chinese herbs that causes progressive interstitial nephritis. The aim of this research is to know whether chymases play the crucial role in AAI-induced nephropathy.
Jia-Ping Wu
doaj   +1 more source

The role of angiotensin I converting enzyme insertion/deletion polymorphism in the severity and outcomes of COVID-19 patients

Frontiers in Genetics, 2022
The pandemic of coronavirus disease in 2019 has led to a global crisis. COVID-19 shows distinct clinical manifestations of the severity of symptoms. Numerous patients with no associated risk factors demonstrate acute respiratory distress syndrome (ARDS).
Mitra Rezaei, Mitra Rezaei, Hadiseh Mohammadpour, Mahya Eftekhari, Mihan Pourabdollah, Farinaz Nasr Azadani, Payam Tabarsi, Majid Marjani, Seyed Ali Ziai   +8 more
doaj   +1 more source

Diferenças entre os sexos na atividade da enzima conversora de angiotensina e na pressão arterial em crianças: um estudo observacional Gender differences in serum angiotensin-converting enzyme activity and blood pressure in children: an observational study

Arquivos Brasileiros de Cardiologia, 2008
FUNDAMENTO: A enzima conversora da angiotensina (ECA), principal enzima do sistema renina-angiotensina (SRA), desempenha um papel importante na regulação da pressão arterial. A atividade enzimática da ECA e sua relação com a pressão arterial (PA) durante
Patricia Landazuri, Claudia Granobles, Nelsy Loango   +2 more
doaj   +1 more source

The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae [PDF]

, 2017
The control of mosquitoes is threatened by the appearance of insecticide resistance and therefore new control chemicals are urgently required. Here we show that inhibitors of mosquito peptidyl dipeptidase, a peptidase related to mammalian angiotensin ...
A Enayati, A Vandingenen, A Vandingenen, ACM Camargo, AD Haddow, C Harrison, CM Rylett, CS Anthony, D Borovsky, D Borovsky, D Borovsky, DW Cushman, DW Cushman, E Lemeire, EG Erdos, EK Thomsen, G Wijffels, H Ranson, HR Corradi, HR Corradi, JJ Xu, K Arnold, K Hens, KR Acharya, L Bordoli, L Vercruysse, M Akif, M Akif, M Biasini, MA Hayashi, MA Johansson, MA Ondetti, MJ Cornell, N Basso, N Macours, NS Lamango, NS Lamango, NS Lamango, P Corvol, R Natesh, R Natesh, RE Isaac, RE Isaac, RJ Siviter, RL Soffer, S Burnham, S Kumar, S McNicholas, SH Ferreira, TA Williams, U Ekbote, U Ekbote, UV Ekbote, VR Chintapalli, X Houard   +54 more
core   +4 more sources