Results 31 to 40 of about 113,934,450 (165)

Emerging roles of MT‐MMPs in embryonic development

Developmental Dynamics, Volume 251, Issue 2, Page 240-275, February 2022., 2022
Abstract Membrane‐type matrix metalloproteinases (MT‐MMPs) are cell membrane‐tethered proteinases that belong to the family of the MMPs. Apart from their roles in degradation of the extracellular milieu, MT‐MMPs are able to activate through proteolytic processing at the cell surface distinct molecules such as receptors, growth factors, cytokines ...
Natalia Moracho, Ana I. R. Learte, Emma Muñoz‐Sáez, Miguel A. Marchena, María A. Cid, Alicia G. Arroyo, Cristina Sánchez‐Camacho   +6 more
wiley   +1 more source

Pro‐atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation

The FASEB Journal, Volume 35, Issue 10, October 2021., 2021
Abstract Atherosclerosis is a chronic inflammatory disorder of the vasculature regulated by cytokines. We have previously shown that extracellular signal‐regulated kinase‐1/2 (ERK1/2) plays an important role in serine 727 phosphorylation of signal transducer and activator of transcription‐1 (STAT1) transactivation domain, which is required for maximal ...
Wijdan Al‐Ahmadi, Thomas S. Webberley, Alex Joseph, Ffion Harris, Yee‐Hung Chan, Reem Alotibi, Jessica O. Williams, Alaa Alahmadi, Thomas Decker, Timothy R. Hughes, Dipak P. Ramji   +10 more
wiley   +1 more source

Sarcoidosis: old certainties and new perspectives

Italian Journal of Medicine, 2012
Introduction Sarcoidosis is the paradigm of the internistic disease. It virtually affects every organ and tissue and is characterized by the presence of noncaseating granulomas.
Claudio Tana, Marco Tana, Andrea Mezzetti, Cosima Schiavone   +3 more
doaj   +1 more source

Inhibition of Human Cathepsins B and L by Caffeic Acid and Its Derivatives

Biomolecules, 2020
Caffeic acid (CA) and its derivatives caffeic acid phenethyl ester (CAPE) and chlorogenic acid (CGA) are phenolic compounds of plant origin with a wide range of biological activities. Here, we identify and characterize their inhibitory properties against
Liza Ulčakar, Marko Novinec
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 178, Issue S1, Page S1-S26, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +52 more
wiley   +1 more source

SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center [PDF]

, 2011
As nascent polypeptide chains are synthesized, they pass through a tunnel in the large ribosomal subunit. Interaction between specific nascent chains and the ribosomal tunnel is used to induce translational stalling for the regulation of gene expression.
Roland Beckmann, Daniel N. Wilson, Wilson, D., Wilson Daniel N., Mielke Thorsten, Jens Frauenfeld, Thorsten Mielke, Berninghausen, O., Mielke, T., Hoffmann, T., Beckmann, R., Wilson, Daniel N, Frauenfeld, Jens, Seidelt, B., Birgit Seidelt, Berninghausen, Otto, Berninghausen Otto, Frauenfeld Jens, Bhushan, S., Mielke, Thorsten, Shashi Bhushan, Hoffmann Thomas, Seidelt, Birgit, Bhushan, Shashi, Hoffmann, Thomas, Thomas Hoffmann, Otto Berninghausen, Beckmann, Roland, Seidelt Birgit, Beckmann Roland, Daniel N Wilson, Frauenfeld, J., Bhushan Shashi   +32 more
core   +2 more sources

The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors [PDF]

Iranian Journal of Medical Sciences
Background: The risk of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) is estimated to be far greater than that in the general population.
Samaa Salah Abd-El-Fatah, Maha A. Fathy, Mohamed Ali Alabiad, Raja Aljafil, Mai Ahmed Gobran, Enssaf A. Ahmad, Ashwag S. Alsharidah, Mohammed Alorini, Sulaiman Mohammed Alnasser, Sara A. Awadh, Enas N. Morgan   +10 more
doaj   +1 more source

2A-induced ribosome stalling [PDF]

, 2014
Originally 2A was characterised in foot-and-mouth disease virus. Site directed mutagenesis identified a C-terminus consensus motif [D(V/I)ExNPGP] and it is proposed that 2A interacts with the exit tunnel of the ribosome in a way that a specific peptide ...
Odon, Valèrie
core   +1 more source

Extracellular Vesicles From Human Fallopian Tubes Enhance IVF Embryo Development and Contain Functional Proteins Including YWHAZ

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs) in the mammalian oviduct constitute a key maternal regulatory system that maintains redox balance during early embryogenesis, yet their molecular cargo and functional relevance in human embryos remain poorly defined.
Yuehan Li, Wenjing Xiong, Limin Gao, Mingwei Lv, Fei Li, Rui Long, Chang Liu, Jianbo Wei, Meng Wang, Chenlu Zhang, Qiuyu Yu, Na Guo, Lei Jin, Cong Sui   +13 more
wiley   +1 more source

Identification and properties of a peptidyl dipeptidase in the housefly, Musca domestica, that resembles mammalian angiotensin-converting enzyme [PDF]

Biochemical Journal, 1994
[D-Ala2,Leu5]Enkephalin was readily metabolized by membranes (40,000 g pellet) prepared from heads of the housefly, Musca domestica, with Gly3-Phe4 being the major site of cleavage. This hydrolysis was only partially inhibited (40%) by 10 microM phosphoramidon, an inhibitor of endopeptidase-24.11, but was almost totally abolished in the presence of a ...
N S, Lamango, R E, Isaac
openaire   +2 more sources