Results 11 to 20 of about 113,934,450 (165)

Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor. [PDF]

FEBS J, 2016
Several soil‐derived Actinobacteria produce secondary metabolites that are proven specific and potent inhibitors of the human angiotensin‐I‐converting enzyme (ACE), a key target for the modulation of hypertension through its role in the renin–angiotensin–aldosterone system.
Masuyer G, Cozier GE, Kramer GJ, Bachmann BO, Acharya KR.   +4 more
europepmc   +4 more sources

Association between the polymorphisms of angiotensin converting enzyme (Peptidyl-Dipeptidase A) INDEL mutation (I/D) and Angiotensin II type I receptor (A1166C) and breast cancer among post menopausal Egyptian females

Alexandria Journal of Medicine, 2014
Renin angiotensin system (RAS) is involved in the regulation of cardiovascular homeostasis. Angiotensin (Ang II) is converted from angiotensin I via angiotensin converting enzyme (ACE). Ang II exerts its effects by binding to two types of receptors; AT1R
Rania Mohamed El Sharkawy, Ahmed Mohamed Zaki, Amal Abd El Fattah Kamel, Rania Nabil Bedair, Ahmed Saad Ahmed   +4 more
exaly   +3 more sources

Neutrophil-mediated acute kidney injury and its progression to chronicity [PDF]

iScience
Summary: Neutrophils are primary effectors of the innate immune system, modulating tissue homeostasis and disease through phagocytosis, degranulation, and the release of neutrophil extracellular traps (NETs).
Li Qiu, Chufan Liu, Guanhua Cui, Jiayan Fan, Xiutao Li, Wei Gao, Qing Liu, Yongbo Yu, Zhilei Zhang, Xiangyu Zou   +9 more
doaj   +2 more sources

The metabolism of neuropeptides. Neurokinin A (substance K) is a substrate for endopeptidase-24.11 but not for peptidyl dipeptidase A (angiotensin-converting enzyme) [PDF]

Biochemical Journal, 1985
Both endopeptidase-24.11 and peptidyl dipeptidase A have previously been shown to hydrolyse the neuropeptide substance P. The structurally related peptide neurokinin A is also shown to be hydrolysed by pig kidney endopeptidase-24.11. The identified products indicated hydrolysis at two sites, Ser5-Phe6 and Gly8-Leu9, consistent with the known ...
N M, Hooper, A J, Kenny, A J, Turner
exaly   +3 more sources

The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae [PDF]

, 2005
Background Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (ACE), play important roles in regulating a number of physiological processes.
Lee, A.J., Smith Judith A, Lee, Alison J., Shirras Alan D, Shirras, A.D., Smith, Judith A., Isaac, R.E., Shirras, Alan D., Isaac R Elwyn, Burnham Susan, Smith, J.A., Burnham, Susan, Burnham, S., Lee Alison J, Isaac, R. Elwyn   +14 more
core   +6 more sources

Characterization of substrate specificity and novel autoprocessing mechanism of dipeptidase A from Prevotella intermedia [PDF]

, 2020
Prevotella intermedia, a gram-negative anaerobic rod, is frequently observed in subgingival polymicrobial biofilm from adults with chronic periodontitis. Peptidases in periodontopathic bacteria are considered to function as etiological reagents.
Ohara-Nemoto, Yuko, Kobayakawa, Takeshi, Sarwar, Mohammad Tanvir, Naito, Mariko, Nemoto, Takayuki K.   +4 more
core   +3 more sources

Levels of angiotensin-converting enzyme 1 and 2 in serum and urine of children with Sickle Cell Disease

Brazilian Journal of Nephrology, 2021
Introduction: Sickle cell nephropathy begins in childhood and presents early increases in glomerular filtration, which, over the long term, can lead to chronic renal failure.
Ho Chi Hsien, Dulce Elena Casarini, João Tomas de Abreu Carvalhaes, Fernanda Aparecida Ronchi, Lilian Caroline Gonçalves de Oliveira, Josefina Aparecida Pellegrini Braga   +5 more
doaj   +2 more sources

Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Renin⁃angiotensin system (RAS) plays an important role in maintaining cardiovascular homeostasis, water and electrolyte balance in the body, and angiotensin converting enzyme Ⅱ (ACE2) and its axis of action angiotensin⁃(1⁃7) [Ang⁃(1⁃7)] and Mas receptor (
LIANG He , LIN Jian⁃wen , MO Ming, XIE Lu⁃shuang , DU Shi⁃wei , LIU Yi   +5 more
doaj   +1 more source

Aristolochic acid induces chronic kidney disease in ace knockout mice

International Journal of Preventive Medicine, 2021
Background: Aristolochic acid I (AAI) is an extract from Chinese herbs that causes progressive interstitial nephritis. The aim of this research is to know whether chymases play the crucial role in AAI-induced nephropathy.
Jia-Ping Wu
doaj   +1 more source

Activation of the glycosyl-phosphatidylinositol-anchored membrane dipeptidase upon release from pig kidney membranes by phospholipase C [PDF]

, 1994
Incubation of pig kidney microvillar membranes with Bacillus thuringiensis or Staphylococcus aureus phosphatidylinositol-specific phospholipase C (PI-PLC) resulted in the release of a number of glycosyl-phosphatidylinositol (GPI)-anchored hydrolases ...
Hooper, N. M., Turner, A. J., Brewis, Ian Andrew   +2 more
core   +6 more sources