Results 21 to 30 of about 10,632 (177)

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 178, Issue S1, Page S1-S26, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +52 more
wiley   +1 more source

The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae [PDF]

, 2005
Background Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (ACE), play important roles in regulating a number of physiological processes.
Lee, A.J., Smith Judith A, Lee, Alison J., Shirras Alan D, Shirras, A.D., Smith, Judith A., Isaac, R.E., Shirras, Alan D., Isaac R Elwyn, Burnham Susan, Smith, J.A., Burnham, Susan, Burnham, S., Lee Alison J, Isaac, R. Elwyn   +14 more
core   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +32 more
wiley   +1 more source

SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center [PDF]

, 2011
As nascent polypeptide chains are synthesized, they pass through a tunnel in the large ribosomal subunit. Interaction between specific nascent chains and the ribosomal tunnel is used to induce translational stalling for the regulation of gene expression.
Roland Beckmann, Daniel N. Wilson, Wilson, D., Wilson Daniel N., Mielke Thorsten, Jens Frauenfeld, Thorsten Mielke, Berninghausen, O., Mielke, T., Hoffmann, T., Beckmann, R., Wilson, Daniel N, Frauenfeld, Jens, Seidelt, B., Birgit Seidelt, Berninghausen, Otto, Berninghausen Otto, Frauenfeld Jens, Bhushan, S., Mielke, Thorsten, Shashi Bhushan, Hoffmann Thomas, Seidelt, Birgit, Bhushan, Shashi, Hoffmann, Thomas, Thomas Hoffmann, Otto Berninghausen, Beckmann, Roland, Seidelt Birgit, Beckmann Roland, Daniel N Wilson, Frauenfeld, J., Bhushan Shashi   +32 more
core   +1 more source

Dipeptidyl‐peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis

Molecular Oral Microbiology, Volume 36, Issue 2, Page 145-156, April 2021., 2021
Abstract Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic microorganism that solely utilizes nutritional amino acids as its energy source and cellular constituents. The bacterium is considered to incorporate proteinaceous nutrients mainly as dipeptides, thus exopeptidases that produce dipeptides from polypeptides are ...
Takayuki K. Nemoto, Yuko Ohara Nemoto
wiley   +1 more source

Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality in caenorhabditis elegans [PDF]

, 2007
The FK506-binding proteins (FKBs) represent ubiquitous enzymes that catalyse the rate-limiting peptidyl prolyl cis-trans isomerization step in protein folding. The nematode <i>Caenorhabditis elegans</i> has eight FKBs, three of which (FKB-3, -
Page, Antony P., Eschenlauer, SCP, McCormack, Gillian, Winter, AD, Page, AP, Eschenlauer, Sylvain C. P., McCormack, G, Winter, Alan D.   +7 more
core   +1 more source

Lysis of a Lactococcus lactis dipeptidase mutant and rescue by mutation in the pleiotropic regulator cody [PDF]

, 2020
Lactococcus lactis subsp. cremoris MG1363 is a model for the lactic acid bacteria (LAB) used in the dairy industry. The proteolytic system, consisting of a proteinase, several peptide and amino acid uptake systems, and a host of intracellular peptidases,
Huang, Chenxi, Kok, Jan, Kuipers, Oscar P.; id_orcid, Kuipers, Oscar P., Hernandez-Valdes, Jhonatan A   +4 more
core   +1 more source

The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors [PDF]

Iranian Journal of Medical Sciences
Background: The risk of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) is estimated to be far greater than that in the general population.
Samaa Salah Abd-El-Fatah, Maha A. Fathy, Mohamed Ali Alabiad, Raja Aljafil, Mai Ahmed Gobran, Enssaf A. Ahmad, Ashwag S. Alsharidah, Mohammed Alorini, Sulaiman Mohammed Alnasser, Sara A. Awadh, Enas N. Morgan   +10 more
doaj   +1 more source

Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry [PDF]

, 2020
Peptidyl fluoromethyl ketones occupy a pivotal role in the current scenario of synthetic chemistry, thanks to their numerous applications as inhibitors of hydrolytic enzymes.
Nicola Micale, Citarella A., Micale N., Andrea Citarella   +3 more
core   +1 more source

Peptidyl-prolyl isomerases : A full cast of critical actors in cardiovascular diseases [PDF]

, 2015
Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in
G.L. Perrucci, P. Nigro, M. Zanobini, M. C. Capogrossi, A. Gowran, G. Pompilio   +5 more
core   +1 more source