Results 41 to 50 of about 10,632 (177)
Food Science &Nutrition, Volume 12, Issue 10, Page 8309-8323, October 2024.HFD‐treated mice exhibited notable alternations in the structure and composition of the gut microbiota, with some of these alternations being associated with the pathogenesis of IBD. Analysis of the colon transcriptome revealed 11 hub genes and 7 hub pathways among control, DSS‐induced colitis, and HFD + DSS‐treated groups. Impact of HFD on DSS‐induced
Yuyang Zhao +8 more
wiley +1 more source
, 2014 Originally 2A was characterised in foot-and-mouth disease virus. Site directed mutagenesis identified a C-terminus consensus motif [D(V/I)ExNPGP] and it is proposed that 2A interacts with the exit tunnel of the ribosome in a way that a specific peptide ...
Odon, Valèrie
core +1 more source
Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors
, 2008 To evaluate N-hydroxyurea as zinc binding group in the design of MMP inhibitors, two peptidyl 1-hydroxyureas were prepared by N-hydroxycarbamoylation of the diastereomeric dipeptides H-Leu-Phe-NHMe and H-d-Leu-Phe-NHMe.
CAMPESTRE C +7 more
core +3 more sources
Macromolecular Bioscience, Volume 24, Issue 7, July 2024.Organelle‐targeted delivery and release can maximize therapeutic effects and minimize unwanted effects. In addition, when triggering the release of payloads from nanosized drug delivery systems, spending stimulus in the target organelle can create an imbalance of intracellular regulators (e.g., redox), resulting in synergism in therapeutic outcomes ...
Hana Cho +6 more
wiley +1 more source
A Di Copper Peptidyl Complex Mimics Catalase Activity in HeLa HyPer Cells
, 2020 In this manuscript, we describe the implementation of a combinatorial apporach to synthesize a library of copper complexes, associated with an activity-based screening to discover the first peptidyl di copper complex mimicking CAT redox chemistry.
Evangelia, Trigoni +9 more
core +1 more source
Effect of Reno vascular Hypertension Model on Spermatogenesis in Rat
پزشکی بالینی ابن سینا, 2008 Introduction & Objective: Change in function of general and regional rennin- angiotensin system is the most important factor in cardiovascular disorders and essential hypertension.
Iraj Salehi +2 more
doaj
Molecular basis of selective amyloid‐β degrading enzymes in Alzheimer's disease
The FEBS Journal, Volume 291, Issue 14, Page 2999-3029, July 2024.Understanding Aβ clearance by amyloid‐degrading enzymes (ADEs) is of utmost importance due to its direct association with Alzheimer's disease (AD). Aβ is a toxic peptide that aggregates in the brain, leading to amyloid plaques and neurodegeneration.
Joanna Żukowska +3 more
wiley +1 more source
, 2008 Devido aos problemas, ambientais e à população humana, causados pelos inseticidas químicos, novas investigações para o controle de insetos tornaram-se necessárias.
Oliveira, Érica Moreira de +1 more
core +1 more source
Inhibition of human peptidyl dipeptidase (angiotensin I converting enzyme: kininase II) by human serum albumin and its fragments. [PDF]
Hypertension, 1979 Purified peptidyl dipeptidase (angiotensin I converting enzyme or kininase II) from human lung or hog kidney is inhibited by commercially prepared plasma protein preparations, by human serum albumin and by the additive albumin stabilizer, acetyltryptophan.
R J, Klauser +3 more
openaire +2 more sources
, 2016 Here we report a new experimental approach to characterize recombinant nonribosomal peptide cyclases that do not show activity with conventional N-acetylcysteamine (SNAC) substrates.
Mohamed A. Marahiel (226111) +2 more
core +1 more source