Results 41 to 50 of about 6,534 (185)

Pericardial Parietal Mesothelial Cells: Source of the Angiotensin-Converting-Enzyme of the Bovine Pericardial Fluid

Arquivos Brasileiros de Cardiologia
Background: Angiotensin II (Ang II), the primary effector hormone of the renin-angiotensin system (RAS), acts systemically or locally, being produced by the action of angiotensin-converting-enzyme (ACE) on angiotensin I.
Ilsione Ribeiro de Sousa Filho, Isabela Cabral Cavicchioli Pereira, Lourimar José de Morais, Livia das Graças Vieito Lombardi Teodoro, Maria Laura Pinto Rodrigues, Roseli Aparecida da Silva Gomes   +5 more
doaj   +1 more source

Genome-wide gene expression profiling analysis of and developmental stages reveals substantial differences between the two species [PDF]

, 2008
Background Leishmania parasites cause a diverse spectrum of diseases in humans ranging from spontaneously healing skin lesions (e.g., L. major) to life-threatening visceral diseases (e.g., L. infantum).
Annie Rochette, Frédéric Raymond, Jean-Michel Ubeda, Martin Smith, Nadine Messier, Sébastien Boisvert, Philippe Rigault, Jacques Corbeil, Marc Ouellette, Barbara Papadopoulou   +9 more
core   +2 more sources

Quantitative Characterization of Gene Regulatory Circuits Associated With Fungal Secondary Metabolism to Discover Novel Natural Products

Advanced Science, Volume 11, Issue 47, December 18, 2024.
An advanced microfluidic platform is created to enable precise characterization of complex multicellular fungal gene regulatory circuits (GRCs) at the single‐cell level. Quantification of GRCs involved in secondary metabolite production provides new insights into gene regulation of fungal secondary metabolism and highlights the potential of synthetic ...
Xinran Xu, Yanhong Sun, Anxin Zhang, Sijia Li, Shu Zhang, Sijing Chen, Chunbo Lou, Lei Cai, Yihua Chen, Chunxiong Luo, Wen‐Bing Yin   +10 more
wiley   +1 more source

Bacterial β-peptidyl aminopeptidases: on the hydrolytic degradation of β-peptides [PDF]

, 2018
The special chemical and biological features of β-peptides have been investigated intensively during recent years. Many studies emphasize the restricted biodegradability and the high metabolic stability of this class of compounds.
Geueke, B., Kohler, H.-P
core  

The Concise Guide to PHARMACOLOGY 2015/16:Enzymes [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Fabbro, D, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +151 more
core   +4 more sources

Multiomics analysis reveals the potential mechanism of high‐fat diet in dextran sulfate sodium‐induced colitis mice model

Food Science &Nutrition, Volume 12, Issue 10, Page 8309-8323, October 2024.
HFD‐treated mice exhibited notable alternations in the structure and composition of the gut microbiota, with some of these alternations being associated with the pathogenesis of IBD. Analysis of the colon transcriptome revealed 11 hub genes and 7 hub pathways among control, DSS‐induced colitis, and HFD + DSS‐treated groups. Impact of HFD on DSS‐induced
Yuyang Zhao, Zhimin Chen, Ruiyi Dong, Yufan Liu, Yixin Zhang, Yan Guo, Meiyi Yu, Xiang Li, Jiangbin Wang   +8 more
wiley   +1 more source

Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration:disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling [PDF]

, 2016
The Notch ligand Jagged1 is subject to regulated intramembrane proteolysis (RIP) which yields a soluble ectodomain (sJag) and a soluble Jagged1 intracellular domain (JICD). The full-length Jagged1 protein enhances prostate cancer (PCa) cell proliferation
Brown, Mick, Clarke, Noel, Delury, Craig Phillip, Hart, Claire, Parkin, Edward Thomas   +4 more
core   +1 more source

Beyond Nanoparticle‐Based Intracellular Drug Delivery: Cytosol/Organelle‐Targeted Drug Release and Therapeutic Synergism

Macromolecular Bioscience, Volume 24, Issue 7, July 2024.
Organelle‐targeted delivery and release can maximize therapeutic effects and minimize unwanted effects. In addition, when triggering the release of payloads from nanosized drug delivery systems, spending stimulus in the target organelle can create an imbalance of intracellular regulators (e.g., redox), resulting in synergism in therapeutic outcomes ...
Hana Cho, Kang Moo Huh, Min Suk Shim, Yong‐Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang   +6 more
wiley   +1 more source

Effect of Reno vascular Hypertension Model on Spermatogenesis in Rat

پزشکی بالینی ابن سینا, 2008
Introduction & Objective: Change in function of general and regional rennin- angiotensin system is the most important factor in cardiovascular disorders and essential hypertension.
Iraj Salehi, Seyyed Mansour Malakoti, Behnam Heshmatian   +2 more
doaj  

Molecular basis of selective amyloid‐β degrading enzymes in Alzheimer's disease

The FEBS Journal, Volume 291, Issue 14, Page 2999-3029, July 2024.
Understanding Aβ clearance by amyloid‐degrading enzymes (ADEs) is of utmost importance due to its direct association with Alzheimer's disease (AD). Aβ is a toxic peptide that aggregates in the brain, leading to amyloid plaques and neurodegeneration.
Joanna Żukowska, Stephen J. Moss, Vasanta Subramanian, K. Ravi Acharya   +3 more
wiley   +1 more source