Results 51 to 60 of about 10,632 (177)

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

Signal Transduction and Targeted Therapy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients.
Xinyi Yang, Xu Zheng, Yuqi Zhu, Xiaying Zhao, Jun Liu, Jiangna Xun, Songhua Yuan, Jun Chen, Hanyu Pan, Jinlong Yang, Jing Wang, Zhimin Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Min Li, Fei Peng, Daru Lu, Jianqing Xu, Hongzhou Lu, Shibo Jiang, Ping Zhao, Huanzhang Zhu   +23 more
doaj   +1 more source

Terapia com inibidor da ECA com dosagens relativamente altas e risco de agravamento renal na insuficiência cardíaca crônica ACE-inhibitor therapy at relatively high doses and risk of renal worsening in chronic heart failure

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: O efeito renoprotetor dos inibidores da ECA vem sendo questionado no caso de diminuição do volume circulante efetivo, como na insuficiência cardíaca crônica direita ou biventricular.
Renato De Vecchis, Giuseppina Di Biase, Carmelina Ariano, Carmela Cioppa, Anna Giasi, Antonio Ciccarelli, Armando Pucciarelli, Salvatore Cantatrione   +7 more
doaj  

Activation of the glycosyl-phosphatidylinositol-anchored membrane dipeptidase upon release from pig kidney membranes by phospholipase C [PDF]

, 1994
Incubation of pig kidney microvillar membranes with Bacillus thuringiensis or Staphylococcus aureus phosphatidylinositol-specific phospholipase C (PI-PLC) resulted in the release of a number of glycosyl-phosphatidylinositol (GPI)-anchored hydrolases ...
Hooper, N. M., Turner, A. J., Brewis, Ian Andrew   +2 more
core  

Distribution of peptidyl-glycine alpha-amidating mono-oxygenase (PAM) enzymes in normal human lung and in lung epithelial tumors [PDF]

, 1996
C-terminal alpha-amidation is a post-translational modification necessary for the biological activity of many regulatory peptides produced in the respiratory tract. This modification is a two-step process catalyzed by two separate enzyme activities, both
Saldise, L. (Laura), Polak, J.M. (Julia M.), L Saldise, L M Montuenga, A Martínez, Springall, D.R. (David R.), J M Polak, Martínez, Alfredo [0000-0003-4882-4044], Vazquez, J.J. (Jesús Jaime), Martinez, A. (Alfredo), Montuenga-Badia, L.M. (Luis M.), Vázquez, Jesús J., Treston, A.M. (Anthony M.), J J Vázquez, Treston, Anthony, Saldise, Laura, Polak, Julia M., A Treston, Montuenga, Luis M. [0000-0002-8739-1387], Springall, David R., D R Springall   +20 more
core   +1 more source

A Dipeptidase from Escherichia Coli

, 1978
An enzyme in which resides the majority of the L-alanylglycine hydrolysis activity of Escherichia coli K-12 has been partially purified and characterized. The intracellular enzyme which is not particle—bound appears to be a dipeptidase.
Belliveau, Mauricee
core  

Biochemical Characterization of a Novel Alkaline-Tolerant Xaa-Pro Dipeptidase from Aspergillus phoenicis

, 2023
Xaa-Pro dipeptidase (XPD, EC 3.4.13.9; also known as prolidase) catalyzes the hydrolysis of the iminopeptide bond in the trans-Xaa-Pro dipeptides (Xaa represents any amino acid except proline), which makes it find wide applications in food, medical and ...
Zixing Dong, Cunduo Tang, Kun Zhang, Yunchao Kan, Shuangshuang Yang, Lunguang Yao   +5 more
core   +1 more source

Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease

, 2015
Peptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds.
Terrence Piva (18029737), Wenhua Zheng (2222941), Hossein Rezaei (2890355), Danielle Kamato (4255915), Peter Little AM (18043684), Muhamad Rostam (20035368), Narin Derrick (18031564)   +6 more
core  

Membrane Dipeptidase in the Pig Exocrine Pancreas: Ultrastructural Localization and Secretion

, 1998
The GPI-anchored membrane dipeptidase is the major peptidase activity of the secretory granule membrane in the exocrine pancreas. The enzyme is also found in the granule content and in pancreatic secretions.
Gilles Grondin, Denis LeBel, Sarah Cook, Nigel M. Hooper   +3 more
core   +1 more source

The Inactivation of [Met5]-Enkephalin by Bestatin-Sensitive Aminopeptidase, Captopril-Sensitive Peptidyl Dipeptidase A and Thiorphan-Sensitive Endopeptidase-24.11 in Mouse Vas Deferens

Japanese Journal of Pharmacology, 1986
The enkephalin-hydrolyzing peptidases in mouse vas deferens were studied and compared with those in guinea pig ileum which had been characterized in the previous study. The present results showed that three distinct peptidases, bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A, and thiorphan-sensitive endopeptidase-24.11 ...
AOKI, Kazuko, KAJIWARA, Midori, OKA, Tetsuo   +2 more
openaire   +3 more sources

A liquid chromatography-assisted assay for angiotensin-converting enzyme (peptidyl dipeptidase) in serum.

Clinical Chemistry, 1979
Abstract I describe modification of the spectrophotometric assay described by Cushman and Cheung [biochem. Pharmacol. 20, 1637 (1971)] for serum angiotensin-converting enzyme, with use of "high-pressure" liquid chromatography to measure the hippuric acid end product.
openaire   +2 more sources