Results 51 to 60 of about 113,934,450 (165)

Lysis of a Lactococcus lactis dipeptidase mutant and rescue by mutation in the pleiotropic regulator cody [PDF]

, 2020
Lactococcus lactis subsp. cremoris MG1363 is a model for the lactic acid bacteria (LAB) used in the dairy industry. The proteolytic system, consisting of a proteinase, several peptide and amino acid uptake systems, and a host of intracellular peptidases,
Huang, Chenxi, Kok, Jan, Kuipers, Oscar P.; id_orcid, Kuipers, Oscar P., Hernandez-Valdes, Jhonatan A   +4 more
core   +2 more sources

Beyond Nanoparticle‐Based Intracellular Drug Delivery: Cytosol/Organelle‐Targeted Drug Release and Therapeutic Synergism

Macromolecular Bioscience, Volume 24, Issue 7, July 2024.
Organelle‐targeted delivery and release can maximize therapeutic effects and minimize unwanted effects. In addition, when triggering the release of payloads from nanosized drug delivery systems, spending stimulus in the target organelle can create an imbalance of intracellular regulators (e.g., redox), resulting in synergism in therapeutic outcomes ...
Hana Cho, Kang Moo Huh, Min Suk Shim, Yong‐Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang   +6 more
wiley   +1 more source

Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry [PDF]

, 2020
Peptidyl fluoromethyl ketones occupy a pivotal role in the current scenario of synthetic chemistry, thanks to their numerous applications as inhibitors of hydrolytic enzymes.
Nicola Micale, Citarella A., Micale N., Andrea Citarella   +3 more
core   +1 more source

Molecular basis of selective amyloid‐β degrading enzymes in Alzheimer's disease

The FEBS Journal, Volume 291, Issue 14, Page 2999-3029, July 2024.
Understanding Aβ clearance by amyloid‐degrading enzymes (ADEs) is of utmost importance due to its direct association with Alzheimer's disease (AD). Aβ is a toxic peptide that aggregates in the brain, leading to amyloid plaques and neurodegeneration.
Joanna Żukowska, Stephen J. Moss, Vasanta Subramanian, K. Ravi Acharya   +3 more
wiley   +1 more source

A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide

, 1998
Insect peptidyl-dipeptidase A [angiotensin I-converting enzyme (ACE)I is a soluble single-domain peptidyl-dipeptidase that has many properties in common with the C-domain of mammalian somatic ACE and with the single-domain mammalian germinal ACE ...
Schoofs, Liliane, Veelaert, Dirk, Sajid, M., Corvol, P., Coates, D., Williams, T.A., Isaac, R.E.   +6 more
core   +1 more source

Dipeptidase 1 is a functional receptor for a porcine coronavirus [PDF]

Coronaviruses of the subgenus Embecovirus include several important pathogens, such as the human seasonal coronaviruses HKU1 and OC43, bovine coronavirus and porcine haemagglutinating encephalomyelitis virus (PHEV).
Dufloo, Jérémy, Temperton, Nigel J., Rey, Félix A., Temperton, Nigel, Haouz, Ahmed, Sanjuán, Rafael, Arbabian, Atousa, Gimenez-Lirola, Luis G., Fernández, Ignacio   +8 more
core   +1 more source

PEPTIDYL-DONOR SUBSTRATES FOR RIBOSOMAL PEPTIDYL TRANSFERASE - CHEMICAL SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-ACETYL AMINOACYL DI-NUCLEOTIDES AND TRI-NUCLEOTIDES

, 1972
PEPTIDYL-DONOR SUBSTRATES FOR RIBOSOMAL PEPTIDYL TRANSFERASE - CHEMICAL SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-ACETYL AMINOACYL DI-NUCLEOTIDES AND TRI ...
Julian Mercer (13076475), RH SYMONS (14576042)   +1 more
core   +1 more source

Inhibition of human peptidyl dipeptidase (angiotensin I converting enzyme: kininase II) by human serum albumin and its fragments. [PDF]

Hypertension, 1979
Purified peptidyl dipeptidase (angiotensin I converting enzyme or kininase II) from human lung or hog kidney is inhibited by commercially prepared plasma protein preparations, by human serum albumin and by the additive albumin stabilizer, acetyltryptophan.
R J, Klauser, C J, Robinson, D V, Marinkovic, E G, Erdös   +3 more
openaire   +2 more sources

Terapia com inibidor da ECA com dosagens relativamente altas e risco de agravamento renal na insuficiência cardíaca crônica ACE-inhibitor therapy at relatively high doses and risk of renal worsening in chronic heart failure

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: O efeito renoprotetor dos inibidores da ECA vem sendo questionado no caso de diminuição do volume circulante efetivo, como na insuficiência cardíaca crônica direita ou biventricular.
Renato De Vecchis, Giuseppina Di Biase, Carmelina Ariano, Carmela Cioppa, Anna Giasi, Antonio Ciccarelli, Armando Pucciarelli, Salvatore Cantatrione   +7 more
doaj  

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

Signal Transduction and Targeted Therapy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients.
Xinyi Yang, Xu Zheng, Yuqi Zhu, Xiaying Zhao, Jun Liu, Jiangna Xun, Songhua Yuan, Jun Chen, Hanyu Pan, Jinlong Yang, Jing Wang, Zhimin Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Min Li, Fei Peng, Daru Lu, Jianqing Xu, Hongzhou Lu, Shibo Jiang, Ping Zhao, Huanzhang Zhu   +23 more
doaj   +1 more source