Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Angiotensin-Converting Enzyme (ACE) Inhibitor-Associated Hypersensitivity Vasculitis With Small Bowel Edema: A Case Report. [PDF]
CureusDebbagh L, Zalcman M.
europepmc +1 more source
Evaluation of ACE-inhibitor Induced Laryngeal Edema Using Fiberoptic Scope: A Case Report. [PDF]
J Educ Teach Emerg Med, 2022 Singh J, Danko C.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Pharmacogenomic biomarkers of ACE inhibitor-induced cough in a multi-ethnic UAE cohort. [PDF]
Front PharmacolAltoum SM +6 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Aktivitas Inhibitor Angiotensin Converting Enzyme (ACE) Ekstrak Daging Ikan Gabus (Channa striata).
, 2018 Tingginya prevalensi dan mortalitas akibat hipertensi, telah mendorong dilakukannya kegiatan bioprospeksi untuk mencari senyawa antihipertensi alami dari bahan pangan. Ikan gabus (Channa striata) merupakan salah satu bahan pangan yang berpotensi untuk
Budiari, Setyani
core
Unilateral Tongue and Lip Edema: A Rare Presentation of Angiotensin-Converting Enzyme (ACE) Inhibitor-Induced Angioedema. [PDF]
CureusCarneiro G, Ferreira I, Reigota C.
europepmc +1 more source
Chitosan-Covered Calcium Phosphate Particles Co-Loaded with Superoxide Dismutase 1 and ACE Inhibitor: Development, Characterization and Effect on Intraocular Pressure. [PDF]
Pharmaceutics, 2023 Popova E +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source