Results 1 to 10 of about 60,915 (179)

Hyperpyrexia with hemodynamic instability after sublingual misoprostol: case report and literature review [PDF]

AJOG Global Reports
Misoprostol is widely used in obstetric practice for the prevention and treatment of postpartum hemorrhage due to its uterotonic efficacy, oral administration, and stability at room temperature. Although generally considered safe, rare but severe adverse
Paola A. Castellanos, MD, Juan C. Ureña, MD, Angie J. Acero, MD, Víctor S. Rangel, MD   +3 more
doaj   +2 more sources

Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents

Pharmaceutics, 2021
Acid reducing agents (ARAs) reduce the dissolution rate of weakly basic drugs in the stomach potentially leading to lower bioavailability. Formulating the API as a rapidly dissolving salt is one strategy employed to reduce the impact of ARAs on ...
Siri Kalyan Chirumamilla, Venkatesh Teja Banala, Masoud Jamei, David B. Turner   +3 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study

Pharmaceutics, 2023
Imatinib is mainly metabolised by CYP3A4 and CYP2C8 and is extensively bound to α-acid glycoprotein (AAG). A physiologically based pharmacokinetic (PBPK) model for imatinib describing the CYP3A4-mediated autoinhibition during multiple dosing in ...
Karen Rowland Yeo, Oliver Hatley, Ben G. Small, Trevor N. Johnson   +3 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

Pharmaceutics, 2020
A physiologically based pharmacokinetic (PBPK) model of selegiline (SEL), and its metabolites, was developed in silico to evaluate the disposition differences between healthy and special populations.
Santosh Kumar Puttrevu, Sumit Arora, Sebastian Polak, Nikunj Kumar Patel   +3 more
doaj   +1 more source

Comportamiento físico-mecánico del hormigón adicionando residuos de acero: una revisión literaria

Revista UIS Ingenierías, 2021
En la actualidad, el interés por usar materiales de desecho y subproductos provenientes del hormigón ha incrementado, debido a la necesidad de minimizar la contaminación en el planeta.
Socrates Pedro Muñoz-Pérez, Antonny Luis Cabrera-Alcántara, Carlos César Delgado- Bravo, Paula Alejandra Renilla-Lau   +3 more
doaj   +1 more source

A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle

Journal of Nutritional Science, 2013
Dietary strategies for alleviating health complications associated with type 2 diabetes (T2D) are being pursued as alternatives to pharmaceutical interventions.
Nigel Hoggard, Morven Cruickshank, Kim-Marie Moar, Charles Bestwick, Jens J. Holst, Wendy Russell, Graham Horgan   +6 more
doaj   +1 more source

Desarrollo de aceros reforzados con carburos primarios vía metalurgia líquida

Revista de Metalurgia, 2005
Para que el reforzamiento de los aceros con carburos primarios vía metalurgia líquida sea técnicamente viable se requiere del desarrollo de un tipo de producto reforzante sólido, adecuado para su incorporación al acero, así como de la optimización de ...
I. Agote, M. Gutiérrez, M. Orbegozo, M. Asensio, J. I. Erauskin, L. Á. Erausquin, J. I. Echeverría, J. Roncal   +7 more
doaj   +1 more source

Estudio por difracción de rayos X de los productos de corrosión del acero al carbono

Revista de Metalurgia, 2003
En un estudio anterior se encontró que la tasa de corrosión, de un acero al carbono, decrecía cuando se le sometía al efecto combinado de una mezcla de contaminantes (SO4-2 = 10-4 M + Cl- = 1,5 x 10-3 M).
A. L. Morales
doaj   +1 more source

Physiologically Based Pharmacokinetic Modelling of Hydroxyurea in Patients with Sickle Cell Disease: A Special Focus on Lactating Women and Breastfed Infants to Inform Safe Dosing and Breastfeeding Strategies

Pharmaceuticals
Background/Objectives: Hydroxyurea is currently the standard disease-modifying therapy for reducing sickle cell disease (SCD) complications; however, drug labels currently advise discontinuation of breastfeeding during hydroxyurea therapy due to limited ...
Khaled Abduljalil, Neel Deferm, Anna Murphy, Iain Gardner   +3 more
doaj   +1 more source

Estudio de los tipos de cráteres obtenidos en el impacto de proyectiles 5,56 SS109, sobre blancos de acero AISI-SAE 1045

Revista de Metalurgia, 2000
En el presente trabajo se describe la morfología y formación de los tipos de cráteres obtenidos, en el impacto de proyectiles 5,56 SS109, sobre siete chapas de acero AISI-SAE 1045 que fueron sometidas a diferentes tratamientos térmicos, comparando el ...
Álvaro Castro, Edgar Espejo, Leonardo Martínez   +2 more
doaj   +1 more source