Results 1 to 10 of about 43,694 (231)

Hyperpyrexia with hemodynamic instability after sublingual misoprostol: case report and literature review [PDF]

AJOG Global Reports
Misoprostol is widely used in obstetric practice for the prevention and treatment of postpartum hemorrhage due to its uterotonic efficacy, oral administration, and stability at room temperature. Although generally considered safe, rare but severe adverse
Paola A. Castellanos, MD, Juan C. Ureña, MD, Angie J. Acero, MD, Víctor S. Rangel, MD   +3 more
doaj   +2 more sources

Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents

Pharmaceutics, 2021
Acid reducing agents (ARAs) reduce the dissolution rate of weakly basic drugs in the stomach potentially leading to lower bioavailability. Formulating the API as a rapidly dissolving salt is one strategy employed to reduce the impact of ARAs on ...
Siri Kalyan Chirumamilla, Venkatesh Teja Banala, Masoud Jamei, David B. Turner   +3 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study

Pharmaceutics, 2023
Imatinib is mainly metabolised by CYP3A4 and CYP2C8 and is extensively bound to α-acid glycoprotein (AAG). A physiologically based pharmacokinetic (PBPK) model for imatinib describing the CYP3A4-mediated autoinhibition during multiple dosing in ...
Karen Rowland Yeo, Oliver Hatley, Ben G. Small, Trevor N. Johnson   +3 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

Pharmaceutics, 2020
A physiologically based pharmacokinetic (PBPK) model of selegiline (SEL), and its metabolites, was developed in silico to evaluate the disposition differences between healthy and special populations.
Santosh Kumar Puttrevu, Sumit Arora, Sebastian Polak, Nikunj Kumar Patel   +3 more
doaj   +1 more source

A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle

Journal of Nutritional Science, 2013
Dietary strategies for alleviating health complications associated with type 2 diabetes (T2D) are being pursued as alternatives to pharmaceutical interventions.
Nigel Hoggard, Morven Cruickshank, Kim-Marie Moar, Charles Bestwick, Jens J. Holst, Wendy Russell, Graham Horgan   +6 more
doaj   +1 more source

Desarrollo de aceros reforzados con carburos primarios vía metalurgia líquida

Revista de Metalurgia, 2005
Para que el reforzamiento de los aceros con carburos primarios vía metalurgia líquida sea técnicamente viable se requiere del desarrollo de un tipo de producto reforzante sólido, adecuado para su incorporación al acero, así como de la optimización de ...
I. Agote, M. Gutiérrez, M. Orbegozo, M. Asensio, J. I. Erauskin, L. Á. Erausquin, J. I. Echeverría, J. Roncal   +7 more
doaj   +1 more source

Estudio por difracción de rayos X de los productos de corrosión del acero al carbono

Revista de Metalurgia, 2003
En un estudio anterior se encontró que la tasa de corrosión, de un acero al carbono, decrecía cuando se le sometía al efecto combinado de una mezcla de contaminantes (SO4-2 = 10-4 M + Cl- = 1,5 x 10-3 M).
A. L. Morales
doaj   +1 more source

Diseño y construcción de un equipo de soldadura por fricción con asistencia láser para la unión de ejes de acero AISI 1045 y aluminio 2017-T4

Ingenius: Revista de Ciencia y Tecnología, 2021
La soldadura de materiales disímiles hace que los procesos de soldadura convencional no sean factibles de ser utilizados. La soldadura por fricción, por otro lado, ha demostrado ser una tecnología prometedora capaz de unir materiales sin que la ...
José Luis Mullo, Jorge Andrés Ramos-Grez, Germán Omar Barrionuevo   +2 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modelling of Hydroxyurea in Patients with Sickle Cell Disease: A Special Focus on Lactating Women and Breastfed Infants to Inform Safe Dosing and Breastfeeding Strategies

Pharmaceuticals
Background/Objectives: Hydroxyurea is currently the standard disease-modifying therapy for reducing sickle cell disease (SCD) complications; however, drug labels currently advise discontinuation of breastfeeding during hydroxyurea therapy due to limited ...
Khaled Abduljalil, Neel Deferm, Anna Murphy, Iain Gardner   +3 more
doaj   +1 more source

A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes

Antibodies
The bioavailability of a monoclonal antibody (mAb) or another therapeutic protein after subcutaneous (SC) dosing is challenging to predict from first principles, even if the impact of injection site physiology and drug properties on mAb bioavailability ...
Felix Stader, Cong Liu, Abdallah Derbalah, Hiroshi Momiji, Xian Pan, Iain Gardner, Masoud Jamei, Armin Sepp   +7 more
doaj   +1 more source