Physiologically based pharmacokinetics (PBPK) [PDF]
Drug Metabolism Reviews, 2009 Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical species, and many different approaches have been proposed over the years to improve its predictive performance. Nevertheless, prediction errors are commonly observed in the practical application of simple allometry, for example, in cases where the hepatic ...
Pascal, Espié +4 more
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PBPK Modeling: Empowering Drug Development and Precision Dosing in China [PDF]
CPT: Pharmacometrics & Systems PharmacologyPhysiologically based pharmacokinetic (PBPK) modeling, a cornerstone of model‐informed drug development and model‐informed precision dosing, simulates drug disposition in the human body by integrating physiological, biochemical, and physicochemical ...
Dongsheng Yang +7 more
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Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients [PDF]
Pharmaceutics, 2020 Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging ...
Lukas Kovar +7 more
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PBPK modeling and simulation in drug research and development [PDF]
Acta Pharmaceutica Sinica B, 2016 Physiologically based pharmacokinetic (PBPK) modeling and simulation can be used to predict the pharmacokinetic behavior of drugs in humans using preclinical data. It can also explore the effects of various physiologic parameters such as age, ethnicity, or disease status on human pharmacokinetics, as well as guide dose and dose regiment selection and ...
Xiaomei Zhuang, Chuang Lu
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Making PBPK models more reproducible in practice [PDF]
Briefings in BioinformaticsAbstract Systems biology aims to understand living organisms through mathematically modeling their behaviors at different organizational levels, ranging from molecules to populations. Modeling involves several steps, from determining the model purpose to developing the mathematical model, implementing it computationally, simulating the ...
Elena Domínguez Romero +8 more
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Applications of PBPK Modeling to Estimate Drug Metabolism and Related ADME Processes in Specific Populations [PDF]
PharmaceuticsBackground: Physiologically based pharmacokinetic (PBPK) models utilize computer-based simulations to predict the pharmacokinetics of drugs. By using mathematical modeling techniques consisting of differential equations to simulate blood flow, tissue ...
Pavani Gonnabathula +4 more
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Integration of Machine Learning With PBPK and QSAR Modeling Approaches to Facilitate Drug Discovery and Development [PDF]
CPT: Pharmacometrics & Systems PharmacologyThis review examines the application of machine learning (ML) in physiologically based pharmacokinetic (PBPK) modeling through improved prediction of input parameters, particularly via quantitative structure–activity relationship (QSAR) models, for ...
Xinyue Chen, Zhoumeng Lin
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Population Physiologically‐Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease [PDF]
CPT: Pharmacometrics & Systems PharmacologyPediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions.
Yumi Cleary +4 more
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High-performance PBPK model for predicting CYP3A4 induction-mediated drug interactions: a refined and validated approach [PDF]
Frontiers in PharmacologyIntroductionThe cytochrome P450 enzyme 3A4 (CYP3A4) mediates numerous drug-drug interactions (DDIs) by inducing the metabolism of co-administered drugs, which can result in reduced therapeutic efficacy or increased toxicity.
Cheng-Guang Yang +5 more
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PBPK models in risk assessment—A focus on chloroprene [PDF]
Chemico-Biological Interactions, 2007 Mathematical models are increasingly being used to simulate events in the exposure-response continuum, and to support quantitative predictions of risks to human health. Physiologically based pharmacokinetic (PBPK) models address that portion of the continuum from an external chemical exposure to an internal dose at a target site.
DeWoskin, Robert S.
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