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A Workflow for Global Sensitivity Analysis of PBPK Models [PDF]
Frontiers in Pharmacology, 2011 Physiologically based pharmacokinetic (PBPK) models have a potentially significant role in the development of a reliable predictive toxicity testing strategy. The structure of PBPK models are ideal frameworks into which disparate in vitro and in vivo data can be integrated and utilized to translate information generated, using alternative to animal ...
Kevin Mcnally, Mcnally Kevin
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PBPK modeling and simulation in drug research and development
Acta Pharmaceutica Sinica B, 2016 Physiologically based pharmacokinetic (PBPK) modeling and simulation can be used to predict the pharmacokinetic behavior of drugs in humans using preclinical data. It can also explore the effects of various physiologic parameters such as age, ethnicity, or disease status on human pharmacokinetics, as well as guide dose and dose regiment selection and ...
Xiaomei Zhuang, Chuang Lu
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Frontiers in ToxicologyIntroductionWe previously developed a PBPK model template that consists of a single model “superstructure” with equations and logic found in many physiologically based pharmacokinetic (PBPK) models. Using the template, one can implement PBPK models with different combinations of structures and features.MethodsTo identify factors that influence ...
D F Kapraun +2 more
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Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2016 The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled ...
Kuepfer, L +8 more
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Modelling and PBPK Simulation in Drug Discovery [PDF]
The AAPS Journal, 2009 Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential equations and have been implemented in a number of commercial software packages. These models require species-specific and compound-specific input parameters and allow for the prediction of plasma and tissue concentration time profiles after intravenous and ...
Hannah M, Jones +2 more
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Physiologically Based Pharmacokinetic (PBPK) Models for Ethanol [PDF]
IEEE Transactions on Biomedical Engineering, 2008 Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for ...
Martin H. Plawecki +4 more
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Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2015 The US Food and Drug Administration (FDA) public workshop, entitled “Application of Physiologically‐based Pharmacokinetic (PBPK) Modeling to Support Dose Selection focused on the role of PBPK in drug development and regulation. Representatives from industry, academia, and regulatory agencies discussed the issues within plenary and panel discussions ...
Wagner, C +6 more
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A Delayed Nonlinear PBPK Model for Genistein Dosimetry in Rats [PDF]
Bulletin of Mathematical Biology, 2006 Genistein is an endocrine-active compound (EAC) found in soy products. It has been linked to beneficial effects such as mammary tumor growth suppression and adverse endocrine-related effects such as reduced birth weight in rats and humans. In its conjugated form, genistein is excreted in the bile, which is a significant factor in its pharmacokinetics ...
Zager, Michael G. +2 more
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ZeroPM piece 12 PBPK modelling
ZeroPM Pieces, 2022 ZeroPM piece 12 about PBPK modelling. The presentation can be viewed as a film on the ZeroPM youtube channel.
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PBPK models in risk assessment—A focus on chloroprene
Chemico-Biological Interactions, 2007 Mathematical models are increasingly being used to simulate events in the exposure-response continuum, and to support quantitative predictions of risks to human health. Physiologically based pharmacokinetic (PBPK) models address that portion of the continuum from an external chemical exposure to an internal dose at a target site.
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