CPT: Pharmacometrics & Systems Pharmacology, 2023 The pharmacokinetics (PKs) and safety of medications in particular groups can be predicted using the physiologically‐based pharmacokinetic (PBPK) model.
Xu Zhou +5 more
doaj +1 more source
Model reduction in mathematical pharmacology: integration, reduction and linking of PBPK and systems biology models [PDF]
, 2018 In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration across multiple scales.
Snowden, Thomas J. +2 more
core +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Improved scientific basis for human health risk assessment factors by toxicokinetic population modeling [PDF]
, 2013 Exposure limits or guidelines are derived to protect humans from adverse effects caused by exposure to chemical substances in the environment or at the workplace. The internal dose of a chemical is determined by toxicokinetic (TK) processes such as
Mörk, Anna-Karin
core +1 more source
Modélisation physiologique des interactions métaboliques [PDF]
, 2009 National audienceModeling metabolic interactions between chemicals can be a task of formidable complexity. Here I present a new approach and new tools to facilitate that development.
Bois, Frédéric Y.
core +3 more sources
Integration of Genome Scale Metabolic Networks and gene regulation of metabolic enzymes with Physiologically Based Pharmacokinetics [PDF]
, 2017 The scope of Physiologically Based Pharmacokinetic (PBPK) modelling can be expanded by assimilation of the mechanistic models of intracellular processes from Systems Biology field.
Al Olama +51 more
core +2 more sources
An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science
Toxics, 2023 A physiologically-based pharmacokinetic (PBPK) model represents the structural components of the body with physiologically relevant compartments connected via blood flow rates described by mathematical equations to determine drug disposition. PBPK models
Kiara Fairman +6 more
doaj +1 more source
Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range [PDF]
, 2016 Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility.
Bernard Faller +3 more
core +3 more sources
PRT to predict pharmacokinetic profiles as part of a bioequivalence study of the drug deferasirox
Разработка и регистрация лекарственных средствIntroduction. Deferasirox is a complexing drug and belongs to class II according to the biopharmaceutical classification system (BCS), has acidic properties and belongs to subclass “a” (acid).
A. V. Suvorova +6 more
doaj +1 more source
PLoS Computational Biology, 2016 Developing physiologically-based pharmacokinetic (PBPK) models for chemicals can be resource-intensive, as neither chemical-specific parameters nor in vivo pharmacokinetic data are easily available for model construction.
Jingtao Lu +12 more
doaj +1 more source