Results 31 to 40 of about 11,787 (237)

Physiologically Based Pharmacokinetic (PBPK) Models for Ethanol [PDF]

IEEE Transactions on Biomedical Engineering, 2008
Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for ...
Martin H. Plawecki, Jae-Joon Han, Peter C. Doerschuk, Vijay A. Ramchandani, Sean J. O'Connor   +4 more
openaire   +3 more sources

Physiologically based pharmacokinetic and toxicokinetic modeling: A multidisciplinary approach to drug development and ecotoxicology [PDF]

Hospital Pharmacology
Introduction: Physiologically based pharmacokinetic (PBPK) modeling is a powerful tool in pharmaceutical research and drug development, offering accurate predictions of drug absorption, distribution, metabolism, and elimination (ADME).
Todorović Nemanja B., Ćoškov Aleksandra D., Andrić Nebojša Lj., Stanić Bojana Đ., Milijašević Boris Ž., Milošević Nataša P., Janković Slobodan M., Lalić-Popović Mladena N.   +7 more
doaj   +1 more source

Development and Evaluation of Physiologically Based Pharmacokinetic Drug–Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations

Pharmaceutics, 2019
The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug−disease models by allowing incorporation of relevant pathophysiological changes.
Muhammad F. Rasool, Sundus Khalid, Abdul Majeed, Hamid Saeed, Imran Imran, Mohamed Mohany, Salim S. Al-Rejaie, Faleh Alqahtani   +7 more
doaj   +1 more source

Model-Informed Precision Dosing of Antibiotics in Osteoarticular Infections

Infection and Drug Resistance, 2022
Lingling Liu,1 Jin Wang,1 Huan Zhang,1 Mengli Chen,2 Yun Cai1 1Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pharmacy, Medical Supplies ...
Liu L, Wang J, Zhang H, Chen M, Cai Y
doaj  

Current and future physiologically based pharmacokinetic (PBPK) modeling approaches to optimize pharmacotherapy in preterm neonates [PDF]

, 2022
INTRODUCTION: There is a need for structured approaches to inform on pharmacotherapy in preterm neonates. With their proven track record up to regulatory acceptance, physiologically based pharmacokinetic (PBPK) modeling and simulation provide a ...
Allegaert, Karel, Olafuyi, Olusola, Annaert, Pieter, Abbasi, Mohammad Yaseen, Allegaert, Karel; id_orcid   +4 more
core   +2 more sources

PBPK-based in vivo contextualization of in vitro toxicity data (PICD).

, 2017
INPUT: At the organism level, PBPK models are developed for specific drugs. At the cellular level, in vitro response data of compound-treated primary hepatocytes are analyzed (28).
Lorenzo Fabbri (3712408), Christoph Thiel (386935), Henrik Cordes (3712405), Lars Kuepfer (31319), Hélène Eloise Aschmann (3712411), Vanessa Baier (3712420), Ines Smit (3712417), Lars Mathias Blank (3712414), Francis Atkinson (3712423)   +8 more
core   +1 more source

Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling

Frontiers in Pharmacology, 2022
This study aimed to apply a physiologically based pharmacokinetic (PBPK) model to predict optimal dosing regimens of pazopanib (PAZ) for safe and effective administration when co-administered with CYP3A4 inhibitors, acid-reducing agents, food, and ...
Chunnuan Wu, Chunnuan Wu, Chunnuan Wu, Bole Li, Bole Li, Bole Li, Shuai Meng, Shuai Meng, Shuai Meng, Linghui Qie, Linghui Qie, Linghui Qie, Jie Zhang, Jie Zhang, Jie Zhang, Guopeng Wang, Cong Cong Ren   +16 more
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Predicting the correct dose in children: Role of computational Pediatric Physiological‐based pharmacokinetics modeling tools

CPT: Pharmacometrics & Systems Pharmacology, 2023
The pharmacokinetics (PKs) and safety of medications in particular groups can be predicted using the physiologically‐based pharmacokinetic (PBPK) model.
Xu Zhou, Jiening Dun, Xiao Chen, Bai Xiang, Yunjie Dang, Deying Cao   +5 more
doaj   +1 more source

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2015
The US Food and Drug Administration (FDA) public workshop, entitled “Application of Physiologically‐based Pharmacokinetic (PBPK) Modeling to Support Dose Selection focused on the role of PBPK in drug development and regulation. Representatives from industry, academia, and regulatory agencies discussed the issues within plenary and panel discussions ...
Wagner, C, Zhao, P, Pan, Y, Hsu, V, Grillo, J, Huang, SM, Sinha, V   +6 more
openaire   +2 more sources

Physiologically-based pharmacokinetic modeling: past, present and future (review)

Разработка и регистрация лекарственных средств
Introduction. Physiologically-based pharmacokinetic modelling is a method that allows predicting the distribution of drugs in the body based on anatomical and physiological parameters.
N. S. Bagaeva, E. I. Evtyukhina, D. S. Shchelgacheva, M. O. Popova, O. A. Archakova, T. N. Komarov, A. N. Marchenko, E. A. Malashenko, I. E. Shohin   +8 more
doaj   +1 more source