Results 41 to 50 of about 11,787 (237)
Gates Open Research, 2023 Physiologically based pharmacokinetic (PBPK) models represent computational technology to characterize drug behavior within the context of detailed human physiology.
Jolien Freriksen +10 more
doaj +1 more source
PRT to predict pharmacokinetic profiles as part of a bioequivalence study of the drug deferasirox
Разработка и регистрация лекарственных средствIntroduction. Deferasirox is a complexing drug and belongs to class II according to the biopharmaceutical classification system (BCS), has acidic properties and belongs to subclass “a” (acid).
A. V. Suvorova +6 more
doaj +1 more source
Advanced Science, EarlyView.Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li +6 more
wiley +1 more source
A Workflow for Global Sensitivity Analysis of PBPK Models [PDF]
Frontiers in Pharmacology, 2011 Physiologically based pharmacokinetic (PBPK) models have a potentially significant role in the development of a reliable predictive toxicity testing strategy. The structure of PBPK models are ideal frameworks into which disparate in vitro and in vivo data can be integrated and utilized to translate information generated, using alternative to animal ...
McNally, Kevin +2 more
openaire +3 more sources
CPT: Pharmacometrics & Systems PharmacologyAccurate physiologically based pharmacokinetic (PBPK) simulation of drug–drug interaction (DDI) potential requires estimation of the relative contribution of the impacted pathway.
Ian E. Templeton +6 more
doaj +1 more source
Advanced Science, EarlyView.Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi +2 more
wiley +1 more source
Integrated multi-scale PBPK/PD model.
, 2019 From left to right: Whole-body model (PBPK): The drug distribution is modelled using the PBPK approach at the level of the human whole-body. Integrated model (PBPK/PD): The integrated model encompasses the dose arriving from the whole-body PBPK model to ...
Jörg Lippert (124210) +7 more
core +1 more source
Autonomous AI‐Driven Design for Skin Product Formulations
Advanced Intelligent Discovery, EarlyView.This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang +5 more
wiley +1 more source
PLoS Computational Biology, 2016 Developing physiologically-based pharmacokinetic (PBPK) models for chemicals can be resource-intensive, as neither chemical-specific parameters nor in vivo pharmacokinetic data are easily available for model construction.
Jingtao Lu +12 more
doaj +1 more source