Results 41 to 50 of about 9,895 (222)

Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling

Frontiers in Pharmacology, 2022
This study aimed to apply a physiologically based pharmacokinetic (PBPK) model to predict optimal dosing regimens of pazopanib (PAZ) for safe and effective administration when co-administered with CYP3A4 inhibitors, acid-reducing agents, food, and ...
Chunnuan Wu, Chunnuan Wu, Chunnuan Wu, Bole Li, Bole Li, Bole Li, Shuai Meng, Shuai Meng, Shuai Meng, Linghui Qie, Linghui Qie, Linghui Qie, Jie Zhang, Jie Zhang, Jie Zhang, Guopeng Wang, Cong Cong Ren   +16 more
doaj   +1 more source

Parameters Used for PBPK Model. [PDF]

, 2013
Parameters Used for PBPK Model.
John Wambaugh (230167), Imran Shah (49110)   +1 more
core   +1 more source

Is a Clinical Trial With a Non-Bioequivalent Batch Necessary? The Critical Role of Intrasubject Variability in Olaparib Formulation Bridging by PBPK. [PDF]

Clin Pharmacol Ther
Although physiologically based pharmacokinetic (PBPK) modeling is increasingly being used to support oral drug formulation bridging, the acceptance by regulatory agencies is low. One of the primary concerns is the absence of clinical pharmacokinetic (PK) data from a non‐bioequivalent (non‐BE) batch during model validation.
Dong J, Moir A, Pepin X, Lowe E, Hopkins S, Tang W, Zhou D.   +6 more
europepmc   +2 more sources

Current Practices, Gap Analysis and Proposed Roadmaps for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective [PDF]

, 2022
The International Consortium for Innovation and Quality (IQ) Physiologically Based Pharmacokinetic modeling (PBPK) Induction Working Group (IWG) conducted a survey across participating companies around general strategies for PBPK modeling of induction ...
Badee, Justine Marine
core   +1 more source

Predicting the correct dose in children: Role of computational Pediatric Physiological‐based pharmacokinetics modeling tools

CPT: Pharmacometrics & Systems Pharmacology, 2023
The pharmacokinetics (PKs) and safety of medications in particular groups can be predicted using the physiologically‐based pharmacokinetic (PBPK) model.
Xu Zhou, Jiening Dun, Xiao Chen, Bai Xiang, Yunjie Dang, Deying Cao   +5 more
doaj   +1 more source

Whole-body PBPK Model Rate Equations. [PDF]

, 2016
Whole-body PBPK Model Rate Equations.
Alin Cosmanescu (3124272), Maciej Swat (57656), Sherry G. Clendenon (204014), Xiao Fu (74654), James A. Glazier (53981), James P. Sluka (3124269), Julio M. Belmonte (204008), John F. Wambaugh (1727491)   +7 more
core   +1 more source

Demystifying physiologically based pharmacokinetic modelling among non-modelers towards model-informed medicine use in under-served populations. [version 1; peer review: 3 approved, 2 approved with reservations]

Gates Open Research, 2023
Physiologically based pharmacokinetic (PBPK) models represent computational technology to characterize drug behavior within the context of detailed human physiology.
Jolien Freriksen, Susan Cole, Joyce van der Heijden, Karen R Yeo, Trevor Johnson, Essam Kerwash, Marika de Hoop-Sommen, Rick Greupink, Janet Nooney, Saskia de Wildt, Ping Zhao   +10 more
doaj   +1 more source

Lumping von PBPK-Modellen und Systembiologie [PDF]

, 2011
In drug discovery and development, pharmacokinetic and pharmacodynamic modeling are successfully applied to analyze and predict the time course of drug concentration and drug effect in the patient.
Pilari, Sabine
core   +1 more source

A Workflow for Global Sensitivity Analysis of PBPK Models [PDF]

Frontiers in Pharmacology, 2011
Physiologically based pharmacokinetic (PBPK) models have a potentially significant role in the development of a reliable predictive toxicity testing strategy. The structure of PBPK models are ideal frameworks into which disparate in vitro and in vivo data can be integrated and utilized to translate information generated, using alternative to animal ...
McNally, Kevin, Cotton, Richard, Loizou, George D.   +2 more
openaire   +3 more sources

PBPK parameters for the compounds considered. [PDF]

, 2014
The table lists the PBPK model parameters for CFDA SE, midazolam, and spiramycin used in our simulations, including literature sources. Molecular weight MW, fraction unbound and lipophilicity are used to calculate the partition coefficients and ...
Tobias Preusser (535384), Lars Ole Schwen (535380), Fabian Kiessling (535383), Lars Kuepfer (31319), Christoph Niederalt (535381), Felix Gremse (535382), Markus Krauss (124200), Andrea Schenk (530847)   +7 more
core   +1 more source