Results 21 to 30 of about 11,787 (237)

Prediction of Monoclonal Antibody Pharmacokinetics in Pediatric Populations Using PBPK Modeling and Simulation

Pharmaceutics
Background: Accurately determining pediatric dosing is essential prior to initiating clinical trials or administering medications in routine clinical settings. In children, ethical considerations demand careful evaluation of both safety and effectiveness.
Chiara Zunino, Virginie Gualano, Haiying Zhou, Viera Lukacova, Maxime Le Merdy   +4 more
doaj   +2 more sources

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2016
The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled ...
Kuepfer, L, Niederalt, C, Wendl, T, Schlender, J‐F, Willmann, S, Lippert, J, Block, M, Eissing, T, Teutonico, D   +8 more
openaire   +2 more sources

Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug-Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray. [PDF]

Clin Pharmacol Ther
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Ke A, Callegari E, Varma MVS, Ladumor MK, Muto C, Bertz RJ, Jones HM, Sahasrabudhe V, Liu J.   +8 more
europepmc   +2 more sources

A new "old" model: PBPK

, 2022
A new "old" model: PBPK.
L. Palazzolo
core   +2 more sources

Heang60/PBPK-Magic-Mushroom: PBPK Code of Magic Mushroom

, 2021
No description ...
Kimheang
core   +1 more source

Physiologically Based Pharmacokinetic Modeling to Characterize the Disposition of Topiramate in Children with and without Obesity. [PDF]

J Clin Pharmacol
Abstract Topiramate (TPM) is used to treat seizures in adults and children ≥2 years. In children, TPM dosing is body weight based. It is unknown whether children with obesity may benefit from an alternative dosing strategy. We developed a novel physiologically based pharmacokinetic (PBPK) model for TPM that accounts for age‐ and obesity‐related changes
Maglalang PD, Gonzalez D, Muller WJ, Hornik CD, Goldstein SL, Rathore M, Ford JL, Balevic SJ, Sinha J, Edginton A, Greenberg RG, Benjamin DK, Chen JY, Zimmerman KO, Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee.   +14 more
europepmc   +2 more sources

Development of Successful Physiologically-Based Pharmacokinetic (PBPK) Models [PDF]

, 2023
Physiologically-based pharmacokinetic (PBPK) modeling is a strong mathematical tool that integrates body physiology, drug physicochemical properties and pharmacokinetics to predict detailed drug profiles in different parts of the body.
Nasir Mohammad Yasir Idkaidek, Idkaidek, Nasir Mohammad Yasir   +1 more
core   +1 more source

Physiologically Based Pharmacokinetic Modelling for Nicotine and Cotinine Clearance in Pregnant Women

Frontiers in Pharmacology, 2021
Introduction: Physiologically based pharmacokinetic (PBPK) models for the absorption, disposition, metabolism and excretion (ADME) of nicotine and its major metabolite cotinine in pregnant women (p-PBPK) are rare. The aim of this short research report is
Basile Amice, Harvey Ho, En Zhang, Chris Bullen   +3 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modelling to Predict Pharmacokinetics of Enavogliflozin, a Sodium-Dependent Glucose Transporter 2 Inhibitor, in Humans

Pharmaceutics, 2023
Enavogliflozin is a sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor approved for clinical use in South Korea. As SGLT2 inhibitors are a treatment option for patients with diabetes, enavogliflozin is expected to be prescribed in various ...
Min-Soo Kim, Yoo-Kyung Song, Ji-Soo Choi, Hye Young Ji, Eunsuk Yang, Joon Seok Park, Hyung Sik Kim, Min-Joo Kim, In-Kyung Cho, Suk-Jae Chung, Yoon-Jee Chae, Kyeong-Ryoon Lee   +11 more
doaj   +1 more source

Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients

Drug Design, Development and Therapy, 2021
Muhammad Nasir Kalam,1 Muhammad Fawad Rasool,2 Faleh Alqahtani,3 Imran Imran,4 Asim Ur Rehman,1 Naveed Ahmed1 1Department of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan; 2Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin ...
Kalam MN, Rasool MF, Alqahtani F, Imran I, Rehman AU, Ahmed N   +5 more
doaj