Results 21 to 30 of about 9,895 (222)

Lost in modelling and simulation?

ADMET and DMPK, 2021
Over the past few decades, physiologically-based pharmacokinetic modelling (PBPK) has been anticipated to be a powerful tool to improve the productivity of drug discovery and development.
Kiyohiko Sugano
doaj   +1 more source

Polymyxin B Intravenous Administration Strategy Guided by Minimum Inhibitory Concentration in Critically Ill Patients With Pulmonary Infection: Insights From PBPK Modeling. [PDF]

CPT Pharmacometrics Syst Pharmacol
PBPK/PD modeling and clinical retrospective validation of intravenous polymyxin B in critically ill patients with pulmonary infection. ABSTRACT Intravenous polymyxin B (PMB) is widely used for treating drug‐resistant gram‐negative pneumonia, though its efficacy in pulmonary infections is considered limited.
Zhang S, Yang N, Yang R, Qin Y, Wu T, Wu C, Xie Y, Liu J, Liu C, Pei Q.   +9 more
europepmc   +2 more sources

Physiologically Based Pharmacokinetic Modelling for Nicotine and Cotinine Clearance in Pregnant Women

Frontiers in Pharmacology, 2021
Introduction: Physiologically based pharmacokinetic (PBPK) models for the absorption, disposition, metabolism and excretion (ADME) of nicotine and its major metabolite cotinine in pregnant women (p-PBPK) are rare. The aim of this short research report is
Basile Amice, Harvey Ho, En Zhang, Chris Bullen   +3 more
doaj   +1 more source

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

Pharmaceutics, 2020
The application of in silico modeling to predict the in vivo outcome of an oral drug product is gaining a lot of interest. Fully relying on these models as a surrogate tool requires continuous optimization and validation.
Marival Bermejo, Bart Hens, Joseph Dickens, Deanna Mudie, Paulo Paixão, Yasuhiro Tsume, Kerby Shedden, Gordon L. Amidon   +7 more
doaj   +1 more source

Development of Successful Physiologically-Based Pharmacokinetic (PBPK) Models [PDF]

, 2023
Physiologically-based pharmacokinetic (PBPK) modeling is a strong mathematical tool that integrates body physiology, drug physicochemical properties and pharmacokinetics to predict detailed drug profiles in different parts of the body.
Nasir Mohammad Yasir Idkaidek, Idkaidek, Nasir Mohammad Yasir   +1 more
core   +2 more sources

PBPK-based in vivo contextualization of in vitro toxicity data (PICD). [PDF]

, 2017
INPUT: At the organism level, PBPK models are developed for specific drugs. At the cellular level, in vitro response data of compound-treated primary hepatocytes are analyzed (28).
Lorenzo Fabbri (3712408), Christoph Thiel (386935), Henrik Cordes (3712405), Lars Kuepfer (31319), Hélène Eloise Aschmann (3712411), Vanessa Baier (3712420), Ines Smit (3712417), Lars Mathias Blank (3712414), Francis Atkinson (3712423)   +8 more
core   +1 more source

Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug–drug interaction

CPT: Pharmacometrics & Systems Pharmacology, 2022
Physiologically‐based pharmacokinetic (PBPK) models have an important role in drug discovery/development and decision making in regulatory submissions.
Luna Prieto Garcia, Anna Lundahl, Christine Ahlström, Anna Vildhede, Hans Lennernäs, Erik Sjögren   +5 more
doaj   +1 more source

Physiologically based pharmacokinetic and toxicokinetic modeling: A multidisciplinary approach to drug development and ecotoxicology [PDF]

Hospital Pharmacology
Introduction: Physiologically based pharmacokinetic (PBPK) modeling is a powerful tool in pharmaceutical research and drug development, offering accurate predictions of drug absorption, distribution, metabolism, and elimination (ADME).
Todorović Nemanja B., Ćoškov Aleksandra D., Andrić Nebojša Lj., Stanić Bojana Đ., Milijašević Boris Ž., Milošević Nataša P., Janković Slobodan M., Lalić-Popović Mladena N.   +7 more
doaj   +1 more source

Modelling and PBPK Simulation in Drug Discovery [PDF]

The AAPS Journal, 2009
Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential equations and have been implemented in a number of commercial software packages. These models require species-specific and compound-specific input parameters and allow for the prediction of plasma and tissue concentration time profiles after intravenous and ...
Hannah M, Jones, Iain B, Gardner, Kenny J, Watson   +2 more
openaire   +2 more sources

A new "old" model: PBPK [PDF]

, 2022
A new "old" model: PBPK.
L. Palazzolo
core