Results 1 to 10 of about 3,131,990 (302)

Distribution of methotrexate in rat tissues

British Journal of Dermatology, 1974
SUMMARY The distribution of methotrexate between tissues is a very complex process, dependent in part upon the species studied, the size of the dose and the channel of administration. The nature of the tissue and its content of dihydrofolate reductase also play a part. Elimination of methotrexate in the urine and bile indicate that renal and hepatic
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Pharmacokinetics and tissue distribution of crotonoside

Xenobiotica, 2017
1. Crotonoside is a bioactive ingredient from Croton Herba with a strong antitumour activity. This study aimed to develop a highly sensitive and selective high-performance liquid chromatography (HPLC) method to quantify crotonoside in biological samples for pharmacokinetics and distribution studies. 2.
Peiao, Yan, Lan, Zhang, Cheng, Peng, Ruoqi, Zhang   +3 more
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Distribution of sirolimus in rat tissue

Clinical Biochemistry, 1997
To examine the distribution of sirolimus (SRL, rapamycin), an immunosuppressive macrolide antibiotic, in the tissues of adult male Wistar-Furth rats following continuous intravenous infusion (CIVI) and repeated daily peroral gavage (PO).Animals received 14-day courses of SRL by either CIVI (0.04-0.4 mg/kg/day) or PO (0.4-1.6 mg/kg/day) administration ...
K L, Napoli, M E, Wang, S M, Stepkowski, B D, Kahan   +3 more
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Phenol: Tissue Distribution in a Fatality

Journal of Forensic Sciences, 1989
Abstract A case is reported where phenol, a disinfectant, was ingested and resulted in the death of a 40-year-old white female. Concentrations of phenol were determined in blood (130 mg/L), urine (47 mg/L), bile (187 mg/L), brain (486 mg/kg), kidney (331 mg/kg), muscle (204 mg/kg), liver (228 mg/kg), and stomach content (668 mg) and ...
C, Lo Dico, Y H, Caplan, B, Levine, D F, Smyth, J E, Smialek   +4 more
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Tissue distribution of exaprolol in rat

European Journal of Drug Metabolism and Pharmacokinetics, 1985
The disposition of the beta adrenoceptor blocking drug 1-(2-cyclohexylphenoxy)-3-isopropylamino-2-propanol, exaprolol, in organs of the rat has been studied. After i.v. administration of 3H-exaprolol a transient extremely high accumulation of the drug in lungs was observed with a peak of 7.7% of dose/g 30 min post-administration.
V, Faberová, T, Trnovec, M, Zemánek, S, Bezek, M, Durisová, O, Tomcíková   +5 more
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DISTRIBUTION AND TURNOVER OF OCTOPAMINE IN TISSUES

Journal of Neurochemistry, 1972
Abstract— Octopamine is a normally occurring amine in several species of animals. Particularly high concentrations are found in the crustacean central nerve cord. In the rat it is specifically localized to sympathetic nerve endings, has a subcellular distribution similar to that of norepinephrine, and is asymmetrically distributed in the CNS.
P B, Molinoff, J, Axelrod
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Tissue distribution of terbinafine in rats

Journal of Pharmaceutical Sciences, 2001
Terbinafine is an allylamine antifungal agent that is highly lipophilic and keratophilic. The aim of this study was to investigate terbinafine distribution in peripheral and visceral tissues after intravenous administration to rats. Terbinafine, 6 mg/kg, was administered to 33 male Sprague-Dawley rats via a jugular vein cannula over 30 s.
M, Hosseini-Yeganeh, A J, McLachlan
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Tissue distribution of transdermal toremifene

Cancer Chemotherapy and Pharmacology, 1997
Toremifene is an orally administered triphenylethylene derivative with antiestrogenic activity that is primarily used in the treatment of patients with metastatic breast cancer. The purpose of this study was to evaluate the therapeutic advantage of local (transdermal) administration of toremifene in several animal models.
L, Soe, G T, Wurz, J U, Mäenpää, G B, Hubbard, T B, Cadman, V J, Wiebe, A P, Theon, M W, DeGregorio   +7 more
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Distribution of Collagenase in Rat Tissues

Nature, 1965
THE demonstration, recently reported from this laboratory1–3, of a collagenolytic system in rat bone-cell homogenates raised several questions regarding its importance in the physiology and pathology of connective tissues4. Since the activity was largely confined to a subcellular particulate fraction exhibiting a number of the features of lysosomes2,3,
J F, Woods, G, Nichols
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Phencyclidine: Tissue Distribution in the Rat

Clinical Toxicology, 1976
This study was performed to provide knowledge of the tissue distribution of phencyclidine and has demonstrated the lipophilic nature of the drug. The distribution of phencyclidine in blood, brain, and adipose tissue of rats has been determined at various time intervals during a 48-hr period.
S H, James, S H, Schnoll
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