Results 31 to 40 of about 8,279,566 (317)

Expression Patterns of PACAP and PAC1R Genes and Anorexigenic Action of PACAP1 and PACAP2 in Zebrafish

Frontiers in Endocrinology, 2019
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with potent suppressive effects on feeding behavior in rodents, chicken, and goldfish. Teleost fish express two PACAPs (PACAP1, encoded by the adcyap1a gene, and PACAP2, encoded
Tomoya Nakamachi, Ayano Tanigawa, Norifumi Konno, Seiji Shioda, Kouhei Matsuda   +4 more
doaj   +1 more source

Human tissue distribution of caspofungin

International Journal of Antimicrobial Agents, 2022
Tissue concentrations of caspofungin were determined in nine clinically relevant tissues taken during routine autopsy of 20 patients who had died during caspofungin treatment or within 23 days of cessation. The highest levels were achieved in liver, with concentrations ranging from ≤0.50 to 91.5 µg/g (0.60 µg/g 21 days after the last administration ...
Jana Marx, Vera Reinstadler, Tiziana Gasperetti, René Welte, Herbert Oberacher, Patrizia Moser, Michael Joannidis, Romuald Bellmann   +7 more
openaire   +2 more sources

Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle - An efficacy study in the hamster [PDF]

, 2002
The development of hemoglobin-based oxygen carriers has been propagated for replacement of the oxygen carrying properties of red blood cells for almost one century.
Nolte, Dirk, Botzlar, Andreas, Steinhauser, Peter   +2 more
core   +1 more source

Absorption, tissue distribution, and excretion of glycycoumarin, a major bioactive coumarin from Chinese licorice (Glycyrrhiza uralensis Fisch)

Frontiers in Pharmacology, 2023
Licorice (Glycyrrhiza uralensis Fisch) is a natural plant resource widely used as a food and herbal medication in China. Glycycoumarin (GCM) is a major coumarin in licorice that possesses several biological activities.
Linhu Ye, Linhu Ye, Linhu Ye, Lei Cheng, Yan Deng, Sen Wang, Xinyu Wu, Shuiping Ou, Qi Chang, Xinqian Zhao, Wen Zhou, Jinghua Yu, Zuqiang Wu   +12 more
doaj   +1 more source

Quantitative analysis of cell types during growth and morphogenesis in Hydra [PDF]

, 1973
Tissue maceration was used to determine the absolute number and the distribution of cell types in Hydra. It was shown that the total number of cells per animal as well as the distribution of cells vary depending on temperature, feeding conditions, and ...
Bode, H., Schaller, H., David, C., Trenkner, E., Gierer, A., David, Charles N., Berking, S., E. Trenkner, H. Bode, H. Schaller, S. Berking, A. Gierer, C. N. David   +12 more
core   +1 more source

Change of metformin concentrations in the liver as a pharmacological target site of metformin after long-term combined treatment with ginseng berry extract

Frontiers in Pharmacology, 2023
Metformin as an oral glucose-lowering drug is used to treat type 2 diabetic mellitus. Considering the relatively high incidence of cardiovascular complications and other metabolic diseases in diabetic mellitus patients, a combination of metformin plus ...
Choong Whan Lee, Byoung Hoon You, Sreymom Yim, Seung Yon Han, Hee-Sung Chae, Hee-Sung Chae, Mingoo Bae, Seo-Yeon Kim, Jeong-Eun Yu, Jieun Jung, Piseth Nhoek, Hojun Kim, Han Seok Choi, Young-Won Chin, Hyun Woo Kim, Young Hee Choi   +15 more
doaj   +1 more source

Preclinical Pharmacokinetics, Tissue Distribution, and Primary Safety Evaluation of Indo5, a Novel Selective Inhibitor of c-Met and Trks

Frontiers in Pharmacology, 2021
The compound [3-(1H-benzimidazol-2-methylene)-5-(2-methylphenylaminosulfo)-2-indolone], known as Indo5, is a novel selective inhibitor of c-Met and Trks, and it is a promising anticancer candidate against hepatocellular carcinoma (HCC).
Teng Luo, Teng Luo, Teng Luo, Fei-Xiang Zhang, Ke Zhao, Hui-Ying Gao, Shou-Guo Zhang, Lin Wang, Gui-Fang Dou, Ting Liu, Miao Yu, Yi-Qun Zhan, Hui Chen, Xiao-Ming Yang, Xiao-Ming Yang, Chang-Yan Li, Chang-Yan Li   +16 more
doaj   +1 more source

Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases

Drug Design, Development and Therapy, 2020
Oscar Ekpenyong, Xiuqing Gao, Jing Ma, Candace Cooper, Linh Nguyen, Omonike A Olaleye, Dong Liang, Huan Xie Department of Pharmaceutical and Environmental Health Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX ...
Ekpenyong O, Gao X, Ma J, Cooper C, Nguyen L, Olaleye OA, Liang D, Xie H   +7 more
doaj  

Pharmacokinetics, Tissue Distribution and Excretion of a Novel Diuretic (PU-48) in Rats

Pharmaceutics, 2018
Methyl 3-amino-6-methoxythieno [2,3-b] quinoline-2-carboxylate (PU-48) is a novel diuretic urea transporter inhibitor. The aim of this study is to investigate the profile of plasma pharmacokinetics, tissue distribution, and excretion by oral dosing of PU-
Zhi-Yuan Zhang, Hua Zhang, Dan Liu, Ying-Yuan Lu, Xin Wang, Pu Li, Ya-Qing Lou, Bao-Xue Yang, Ya-Xin Lou, Chuang Lu, Qiang Zhang, Guo-Liang Zhang   +11 more
doaj   +1 more source

Tumor-induced effects on PO2 distribution in a normal tissue

, 2012
A tumor in a normal tissue will introduce some significant physiological and pathological changes to the adjacent normal tissues. To quantitatively study how the tumor affects the partial oxygen pressure (PO2) distribution in a normal tissue, an improved
Li, Yan, Li, Mao, Mao Li, Peng Wen, Wen, Peng (Paul), Yan Li   +5 more
core   +1 more source