Results 11 to 20 of about 9,895 (222)
Rapid PBPK modeling with the httk model [PDF]
, 2018 A Course on Physiologically Based Pharmacokinetic (PBPK) Modeling Given at ScitoVation Nov ...
John Wambaugh (230167)
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Prediction of Monoclonal Antibody Pharmacokinetics in Pediatric Populations Using PBPK Modeling and Simulation [PDF]
PharmaceuticsBackground: Accurately determining pediatric dosing is essential prior to initiating clinical trials or administering medications in routine clinical settings. In children, ethical considerations demand careful evaluation of both safety and effectiveness.
Chiara Zunino +4 more
doaj +2 more sources
Frontiers in ToxicologyIntroductionWe previously developed a PBPK model template that consists of a single model “superstructure” with equations and logic found in many physiologically based pharmacokinetic (PBPK) models.
Amanda S. Bernstein +3 more
doaj +3 more sources
Predictive modelling and simulation for taming the chance and luck in biologics drug discovery [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Three Pillars of Survival paradigm in the pharmaceutical drug discovery stipulates that a drug candidate is more likely to reach Phase III if it meets the following criteria: 1) it reaches the required tissue compartment, 2) engages the desired target, 3)
Armin Sepp
doaj +1 more source
Exploring Tafamidis Effects Through PBPK-QSP Modelling. [PDF]
PharmaceuticsBackground/Objectives: Tafamidis, a transthyretin kinetic stabilizer, increases circulating transthyretin levels in treated patients. While this effect is well documented, its underlying mechanism remains incompletely understood. This study aimed to evaluate the performance of a Physiologically Based Pharmacokinetic (PBPK) model performance and to ...
Ulaszek S +3 more
europepmc +5 more sources
Heang60/PBPK-Magic-Mushroom: PBPK Code of Magic Mushroom [PDF]
, 2021 No description ...
Kimheang
core +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2022 The phase distribution model, proposed by Atkinson and Begg in 1990, has been widely used for predicting breastmilk‐to‐plasma drug concentration ratio. However, misrepresentations of the equations have been noted in recent publications.
Mian Zhang +5 more
doaj +1 more source
The emerging role of physiologically-based pharmacokinetic/biopharmaceutics modeling in formulation development [PDF]
Arhiv za farmaciju, 2021 Computer-based (in silico) modeling & simulation tools have been embraced in different fields of pharmaceutics for a variety of applications. Among these, physiologically-based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) emerged as a ...
Cvijić Sandra +3 more
doaj +1 more source
Review of the pharmacokinetics of nanodrugs
Nanotechnology Reviews, 2023 Nanodrug delivery systems (NDDSs) are a hotspot of new drug delivery systems with great development potential. They provide new approaches to fighting against diseases.
Shao Xiaotong +4 more
doaj +1 more source
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2016 The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled ...
Kuepfer, L +8 more
openaire +2 more sources