Results 11 to 20 of about 11,787 (237)
Physiologically based pharmacokinetics (PBPK)
Drug Metabolism Reviews, 2009 Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical species, and many different approaches have been proposed over the years to improve its predictive performance.
Watelet, Jean-Baptiste +9 more
core +3 more sources
Making PBPK models more reproducible in practice [PDF]
Briefings in BioinformaticsSystems biology aims to understand living organisms through mathematically modeling their behaviors at different organizational levels, ranging from molecules to populations.
Mazurenko, Stanislav +19 more
core +5 more sources
PBPK Modeling: Empowering Drug Development and Precision Dosing in China
CPT: Pharmacometrics & Systems PharmacologyPhysiologically based pharmacokinetic (PBPK) modeling, a cornerstone of model‐informed drug development and model‐informed precision dosing, simulates drug disposition in the human body by integrating physiological, biochemical, and physicochemical ...
Dongsheng Yang +7 more
doaj +2 more sources
Pharmaceutics, 2020 Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging ...
Lukas Kovar +7 more
doaj +3 more sources
PharmaceuticsBackground: Physiologically based pharmacokinetic (PBPK) models utilize computer-based simulations to predict the pharmacokinetics of drugs. By using mathematical modeling techniques consisting of differential equations to simulate blood flow, tissue ...
Pavani Gonnabathula +4 more
doaj +2 more sources
PBPK models in risk assessment—A focus on chloroprene [PDF]
Chemico-Biological Interactions, 2007 Mathematical models are increasingly being used to simulate events in the exposure-response continuum, and to support quantitative predictions of risks to human health.
DeWoskin, Robert S.
core +4 more sources
Frontiers in ToxicologyIntroductionWe previously developed a PBPK model template that consists of a single model “superstructure” with equations and logic found in many physiologically based pharmacokinetic (PBPK) models.
Amanda S. Bernstein +3 more
doaj +3 more sources
Rapid PBPK modeling with the httk model
, 2018 A Course on Physiologically Based Pharmacokinetic (PBPK) Modeling Given at ScitoVation Nov ...
John Wambaugh (230167)
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High-performance PBPK model for predicting CYP3A4 induction-mediated drug interactions: a refined and validated approach [PDF]
Frontiers in PharmacologyIntroductionThe cytochrome P450 enzyme 3A4 (CYP3A4) mediates numerous drug-drug interactions (DDIs) by inducing the metabolism of co-administered drugs, which can result in reduced therapeutic efficacy or increased toxicity.
Cheng-Guang Yang +5 more
doaj +2 more sources
Development of Physiologically Based Pharmacokinetic (PBPK) Modeling
PharmaceuticsIn this Special Issue, “Development of Physiologically Based Pharmacokinetic (PBPK) Modeling”, readers can find a selection of articles that discuss the most current challenges and advances in this area [...
S\ue1nchez-Dengra, B\ue1rbara +3 more
core +3 more sources