Results 61 to 70 of about 9,895 (222)
An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science
Toxics, 2023 A physiologically-based pharmacokinetic (PBPK) model represents the structural components of the body with physiologically relevant compartments connected via blood flow rates described by mathematical equations to determine drug disposition. PBPK models
Kiara Fairman +6 more
doaj +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
omrichfield/PACE-PBPK-Monte-Carlo__public: PACE-PBPK-Monte-Carlo__public [PDF]
Public Physiologically Based Pharmacokinetic Model of polyamine coester ...
omrichfield
core +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2023 This report summarizes the proceedings for day 2 sessions 1 and 3 of the 2‐day public workshop entitled “Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence Approaches,” a jointly sponsored workshop by the US Food and Drug ...
Fang Wu +17 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The aim of this study was to develop physiologically based pharmacokinetic (PBPK) models capable of simulating cefadroxil concentrations in plasma and tissues in mouse, rat, and human.
Zhongxia Tan +3 more
doaj +1 more source
PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes [PDF]
, 2019 One of the primary objectives of physiologically based pharmacokinetics (PBPK) is the prediction of a drug’s pharmacokinetics just from knowledge of its physicochemical structure.
Levitt, David +2 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden +3 more
wiley +1 more source
Particle and Fibre Toxicology, 2022 Background Physiologically based pharmacokinetic (PBPK) modeling is an important tool in predicting target organ dosimetry and risk assessment of nanoparticles (NPs).
Wei-Chun Chou +5 more
doaj +1 more source
Keywords extraction from PBPK literatures. [PDF]
, 2016 The abstracts in the PBPK knowledgebase were analyzed to identify PBPK-associated word-stems: (A) Frequency of the top 10 species; (B) Frequency of the top 10 life stages; (C) Frequency of the top 10 compartments.
Jingtao Lu (1806880) +12 more
core
British Journal of Clinical Pharmacology, EarlyView.Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert +6 more
wiley +1 more source