Results 71 to 80 of about 9,895 (222)

Approaches to conducting a physiologically relevant test (PRT) in the study of medicines containing substance IIc of the BCS subclass using sorafenib as an example

Разработка и регистрация лекарственных средств
Introduction. Sorafenib is an antineoplastic drug belonging to class IIc according to the biopharmaceutical classification system (BCS) due to the presence of both acidic and basic properties.
A. V. Suvorova, Yu. V. Medvedev, P. A. Losenkova, O. S. Kramarenko, E. A. Malashenko, A. M. Poluyanov, I. E. Shohin   +6 more
doaj   +1 more source

Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator

CPT: Pharmacometrics & Systems Pharmacology, 2022
The Simcyp Simulator is a software platform for population physiologically‐based pharmacokinetic (PBPK) modeling and simulation. It links in vitro data to in vivo absorption, distribution, metabolism, excretion and pharmacokinetic/pharmacodynamic ...
Udoamaka Ezuruike, Mian Zhang, Amita Pansari, Mailys De Sousa Mendes, Xian Pan, Sibylle Neuhoff, Iain Gardner   +6 more
doaj   +1 more source

PBPK and its virtual populations : the impact of physiology on pediatric pharmacokinetic predictions of tramadol [PDF]

, 2019
In pediatric PBPK models, age-related changes in the body are known to occur. Given the sparsity of and the variability associated with relevant physiological parameters, different PBPK software providers may vary in their system's data.
T'jollyn, Huybrecht, Vermeulen, An, Van Bocxlaer, Jan   +2 more
core   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project

Pharmaceutics, 2023
Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants.
Nina Nauwelaerts, Julia Macente, Neel Deferm, Rodolfo Hernandes Bonan, Miao-Chan Huang, Martje Van Neste, David Bibi, Justine Badee, Frederico S. Martins, Anne Smits, Karel Allegaert, Thomas Bouillon, Pieter Annaert   +12 more
doaj   +1 more source

인체 PBPK 모델을 이용한 DEHP의 노출량 평가 [PDF]

, 2013
학위논문 (석사)-- 서울대학교 보건대학원 : 환경보건학과, 2013. 8. 김성균.Di(2-ethylhexyl)phthalate (DEHP)는 PVC 등 플라스틱 제품의 대표적인 가소제로 광범위하게 사용되는 프탈레이트의 한 종류이다. 본 연구에서는 수용체 장기(organs)의 생리학적 구조와 기능을 바탕으로 화학물질의 흡수 (absorption), 분포 (distribution), 대사 (metabolism) 및 배설 (excretion)을 예측하는
김경민
core  

Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants [PDF]

, 2011
Physiologically Based Pharmacokinetic (PBPK) models can be used to determine the internal dose and strengthen exposure assessment. Many PBPK models are available, but they are not easily accessible for field use.
Meredith Ray, Jeffrey Fisher, Moiz Mumtaz, Patricia Ruiz   +3 more
core   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling − Part I: Veterinary drugs on human food safety assessment

Environment International
Veterinary drugs and environmental pollutants can enter food animals and remain as residues in food chains threatening human food safety and health.
Kun Mi, Xue Wu, Zhoumeng Lin
doaj   +1 more source

Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations

CPT: Pharmacometrics & Systems Pharmacology, 2022
There has been a significant increase in the use of physiologically based pharmacokinetic (PBPK) models during the past 20 years, especially for pediatrics.
Trevor N. Johnson, Ben G. Small, Karen Rowland Yeo   +2 more
doaj   +1 more source