Results 81 to 90 of about 11,787 (237)
, 2016 (A) The 2,039 PBPK-related articles are placed into one of three categories: (1) unique chemical PBPK papers (grey), pioneering articles in which specific chemical names have appeared for the first time; (2) non-unique chemical PBPK papers (yellow ...
Jingtao Lu (1806880) +12 more
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Clinical Pharmacology &Therapeutics, EarlyView.Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang +2 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo +4 more
wiley +1 more source
Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation
Clinical Pharmacology &Therapeutics, EarlyView.Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer +9 more
wiley +1 more source
CPT: Pharmacometrics & Systems PharmacologyPediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions.
Yumi Cleary +4 more
doaj +1 more source
Translational physiologically-based pharmacokinetic (PBPK) modeling and simulation to support drug development and pharmacotherapy [PDF]
, 2018 The Physiologically-based Pharmacokinetic (PBPK) approach was successfully used within four projects to meet challenges in drug development and pharmacotherapy.
Moj, Daniel Andreas
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Clinical Pharmacology &Therapeutics, EarlyView.A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda +2 more
wiley +1 more source
CPT: Pharmacometrics & Systems PharmacologyPediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (
James W. T. Yates +26 more
doaj +1 more source
Keywords extraction from PBPK literatures.
, 2016 The abstracts in the PBPK knowledgebase were analyzed to identify PBPK-associated word-stems: (A) Frequency of the top 10 species; (B) Frequency of the top 10 life stages; (C) Frequency of the top 10 compartments.
Jingtao Lu (1806880) +12 more
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