Results 91 to 100 of about 11,787 (237)
omrichfield/PACE-PBPK-Monte-Carlo__public: PACE-PBPK-Monte-Carlo__public
Public Physiologically Based Pharmacokinetic Model of polyamine coester ...
omrichfield
core +1 more source
, 2011 Physiologically Based Pharmacokinetic (PBPK) models can be used to determine the internal dose and strengthen exposure assessment. Many PBPK models are available, but they are not easily accessible for field use.
Meredith Ray +3 more
core +1 more source
Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access
Clinical Pharmacology &Therapeutics, EarlyView.Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian +5 more
wiley +1 more source
ZeroPM piece 12 PBPK modelling
ZeroPM Pieces, 2022 ZeroPM piece 12 about PBPK modelling. The presentation can be viewed as a film on the ZeroPM youtube channel.
openaire +2 more sources
, 2017 Simulated concentration-time curves (lines) for all parent drugs (blue) were assessed with experimental PK profiles (circles) used for developing reference (ref.) or validated (val.) human PBPK models.
Lorenzo Fabbri (3712408) +8 more
core +1 more source
Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta
Clinical Pharmacology &Therapeutics, EarlyView.Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung +12 more
wiley +1 more source
, 2013 학위논문 (석사)-- 서울대학교 보건대학원 : 환경보건학과, 2013. 8. 김성균.Di(2-ethylhexyl)phthalate (DEHP)는 PVC 등 플라스틱 제품의 대표적인 가소제로 광범위하게 사용되는 프탈레이트의 한 종류이다. 본 연구에서는 수용체 장기(organs)의 생리학적 구조와 기능을 바탕으로 화학물질의 흡수 (absorption), 분포 (distribution), 대사 (metabolism) 및 배설 (excretion)을 예측하는
김경민
core
From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs
Clinical Pharmacology &Therapeutics, EarlyView.New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley +1 more source
PharmaceuticsThe aim of this study was to predict the cytochrome P450 3A (CYP3A)-mediated drug–drug interactions (DDIs) between saxagliptin and nicardipine using a physiologically based pharmacokinetic (PBPK) model.
Jeong-Min Lee +3 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus +7 more
wiley +1 more source