Results 91 to 100 of about 14,687 (252)

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

High-performance PBPK model for predicting CYP3A4 induction-mediated drug interactions: a refined and validated approach

Frontiers in Pharmacology
IntroductionThe cytochrome P450 enzyme 3A4 (CYP3A4) mediates numerous drug-drug interactions (DDIs) by inducing the metabolism of co-administered drugs, which can result in reduced therapeutic efficacy or increased toxicity.
Cheng-Guang Yang, Tao Chen, Wen-Teng Si, An-Hai Wang, Hong-Can Ren, Li Wang   +5 more
doaj   +1 more source

SISO APP Searches in Lattices with Tanner Graphs

, 2011
An efficient, low-complexity, soft-output detector for general lattices is presented, based on their Tanner graph (TG) representations. Closest-point searches in lattices can be performed as non-binary belief propagation on associated TGs; soft ...
Ionescu, Dumitru Mihai, Zhu, Haidong
core   +1 more source

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109769/1/cptclpt201378 ...
Bai, J P F, Brouwer, K L R, Chu, X, Elsby, R, Fenner, K, Galetin, A, Korzekwa, K, Lai, Y, Matsson, P, Moss, A, Nagar, S, Polli, J W, Rosania, G R, Sugiyama, Y   +13 more
core   +2 more sources

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Drug Interaction PBPK Modeling: Review of the Literature Exposes the Need for Increased Verification of Model Inputs and Outputs as Part of Credibility Assessment

Clinical and Translational Science
In vitro data are routinely used to support both static and physiologically based pharmacokinetic (PBPK) model‐based drug–drug interaction (DDI) predictions.
David Rodrigues, Christopher R. Gibson, Nina Isoherranen   +2 more
doaj   +1 more source

A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks [PDF]

, 2011
Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multi-scale by nature,
Eissing, Thomas, Küpfer, Lars, Meyer, Michaela, Niederalt, Christoph, Sevestre, Michael, Siegmund, Hans-Ulrich, Solodenko, Juri, Thelen, Kirsten, Telle, Ulrich, Weiss, Wolfgang, Wendl, Thomas, Willmann, Stefan, Becker, Corina, Lippert, Jörg, Block, Michael, Coboeken, Katrin, Gaub, Thomas, Görlitz, Linus, Jaeger, Juergen, Loosen, Roland, Ludewig, Bernd   +20 more
core   +2 more sources

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Estimating metabolic rate for butadiene at steady state using a Bayesian physiologically-based pharmacokinetic model [PDF]

, 2011
In a study of 133 volunteer subjects, demographic, physiologic and pharmacokinetic data through exposure to 1,3-Butadiene (BD) were collected in order to estimate the percentage of BD concentration metabolized at steady state, and to determine whether
Bois, FY, Mezzetti, M, Ngo, L, Ryan, LM, Smith, TJ   +4 more
core   +4 more sources

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source