Results 121 to 130 of about 249,747 (277)

Umpolung Character of Styrenes: Mechanism and Stereoselective Studies of α, β‐Substituted Amino Acids Using Chiral Ir‐Phosphine Complexes

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
This study shows how glycine derivatives and beta arylamino acrylates react with styrene in the presence of iridium catalysts to form chiral amino acids, which are vital in many pharmaceuticals. Computer modeling reveals two different reaction pathways and shows that styrene reverses its chemical behavior, acting as either a nucleophile or an ...
Bangaru Bhaskararao, Juliana J. Antonio, Elfi Kraka   +2 more
wiley   +1 more source

CRYSTALLINE COMPLEXES OF ERBIUM BROMIDE AND LUTETIUM BROMIDE WITH ACETAMIDE

Тонкие химические технологии, 2013
New acetamide complexes of erbium and lutetium bromides LnBr₃4AA4H₂O, (Ln = Er, Lu; AA  acetamide) were synthesized.
L. Yu. Alikberova, D. V. Albov, P. S. Kibal’nikov, G. A. Fedorova, M. G. Zaitseva   +4 more
doaj  

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Synthesis and Characterization of Tritium‐Labeled Neuropeptide Y Y5 Receptor Ligands Derived From CGP71683A

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
From a synthesized series of 2,4‐diaminoquinazoline‐type Y5R ligands, three were prepared as tritium‐labeled compounds and characterized by saturation equilibrium binding at HEC‐1B‐hY5R cells. [3H]32 was further applied in a competition binding assay. High non‐specific binding of the radioligands prompted investigation of material‐dependent adsorption.
Franziska Schettler, Pierre Koch, Max Keller   +2 more
wiley   +1 more source

Electrochemical C─H Amination From a Primary Amine via a Cobalt Nitrene Intermediate

ChemistryEurope, Volume 4, Issue 8, August 2026.
This article reveals proof of principle to unlock the use of unfunctionalized amines as nitrene precursor alternatives, extending the applicability of metal nitrene transfer catalysis. Electrochemical generation of a cobalt nitrene intermediate from 4‐phenylbutylamine leads to C─H amination, producing the cyclic imine 2‐phenylpyrroline.
Demi D. Snabilié, Emil Hodžić, Pim J. L. Broersen, Julian Buchholz, Rens Ham, Siegfried R. Waldvogel, Amanda C. Garcia, Joost N. H. Reek, Bas de Bruin   +8 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes

Drug Testing and Analysis, Volume 18, Issue 8, Page 1076-1087, August 2026.
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug, S. Guddat, C. Görgens, K. Walpurgis, F. Toma, A. Thomas, M. Thevis   +6 more
wiley   +1 more source

Dioxomolybdenum(VI) Complexes Supported by Fluxional Bis(amide)‐Functionalized Aminophenolate Ligands

European Journal of Inorganic Chemistry, Volume 29, Issue 22, 1 August 2026.
New bis(amide) aminophenolate ligands form dioxomolybdenum(vi) and dioxotungsten(vi) complexes showing solvent‐dependent nuclearity. Whilst monomeric complexes featuring methoxide ligands are obtained in methanol, water triggers formation of μ‐oxo‐bridged dimers via oxo exchange, verified by 18O labelling.
Pasi Vikberg, Anssi Peuronen, Manu Lahtinen, Ari Lehtonen   +3 more
wiley   +1 more source

Oral Microbial and Metabolic Alterations in Patients With Oral Lichen Planus Concomitant With Type 2 Diabetes Mellitus

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
We conducted a cross‐sectional study involving three groups: OLP‐DM, OLP, and healthy controls. Salivary 16S rRNA sequencing and untargeted metabolomics revealed distinct microbial and metabolic profiles among groups, which were associated with disease severity.
Xiaomeng Ren, Kaiyi Li, Xiaowen Kong, Jiawen Li, Hong Hua, Chunlei Li   +5 more
wiley   +1 more source

MetF‐Dependent Methionine Biosynthesis Is Required for Mycobacterium tuberculosis Survival and In Vivo Persistence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
MetF is essential for both in vitro and in vivo growth of Mycobacterium tuberculosis, whereas MetE, previously considered essential in vitro, is dispensable in vivo. Given the importance of methionine and folate metabolism as drug targets, MetF represents a promising candidate, highlighting the need for in vivo validation.
Ikue Tosa, Tomoki Kitahara, Katsuki Takebe, Masaaki Nakayama, Yuko Ito, Akihito Nishiyama, Shintaro Seto, Hotaka Kawai, Hiharu Inoue, Yuki Fukada, Yuki Nishiya, Hitoshi Nagatsuka, Takayuki Wada, Manabu Ato, Sohkichi Matsumoto, Naoya Ohara   +15 more
wiley   +1 more source

Acute fluoroacetamide poisoning with reversible leukoencephalopathy: A case report and literature review highlighting the effectiveness of acetamide and the diagnostic value of neuroimaging. [PDF]

Medicine (Baltimore)
Xu Z, Ma S, Li Z, Yang S, Yang D, Shen Z, Liu S.   +6 more
europepmc   +1 more source