Results 101 to 110 of about 249,747 (277)

Synthesis, crystal structure and Hirshfeld surface analysis of 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)-N-(4-fluorophenyl)acetamide (phenytoin analog)

Acta Crystallographica Section E: Crystallographic Communications
The title phenytoin analog 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)-N-(4-fluorophenyl)acetamide, C23H18FN3O3, was synthesized by alkylation of phenytoin with 2-chloro-N-(4-fluorophenyl)acetamide under phase-transfer catalysis conditions and ...
Hajar Ouabane, Chiara Massera, Walid Guerrab, Abdulsalam Alsubari, Joel T. Mague, Youssef Ramli   +5 more
doaj   +1 more source

Biotransformation of Indole to 3-Methylindole by Lysinibacillus xylanilyticus Strain MA

Journal of Chemistry, 2015
An indole-biotransforming strain MA was identified as Lysinibacillus xylanilyticus on the basis of the 16S rRNA gene sequencing. It transforms indole completely from the broth culture in the presence of an additional carbon source (i.e., sodium succinate)
Pankaj Kumar Arora, Kartik Dhar, Rafael Alejandro Veloz García, Ashutosh Sharma   +3 more
doaj   +1 more source

Gut microbiota‐mediated immune and metabolic dysregulation in coronary artery disease progression and prognosis

iMeta, EarlyView.
The gut microbiota has emerged as a metabolically active endocrine‐like organ with a crucial role in coronary artery disease (CAD), yet its contribution to adverse clinical outcomes remains incompletely understood. In this prospective cohort of 319 participants, we integrated metagenomic and metabolomic profiling with longitudinal follow‐up over a ...
Honghong Liu, Siqin Feng, Lifeng Liang, Muyun Tang, Yifei Wang, Yiyang Wang, Zhiyu Zhang, Haiping Xing, Chenhong Zhang, Ran Tian, Shuyang Zhang   +10 more
wiley   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Technical Assessment of Preclinical Noninvasive Imaging Methods for Endometriosis Follow‐Up in Murine Models

iRADIOLOGY, EarlyView.
This schematic rapidly illustrates the diverse imaging modalities used in preclinical endometriosis research. It highlights optical techniques, such as bioluminescence, fluorescence, and nanoparticle‐assisted imaging, alongside non optical approaches like MRI, ultrasound, and PET, which are key tools in advancing diagnostic precision and understanding ...
Peyman Palay, Tayyebeh Zamani‐Badi, Zeinab Ghezelayagh, Kiandokht Kiani   +3 more
wiley   +1 more source

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado, Nicole Berton, Nicoli da Rosa Amaral, Inara Carbonera Biazus, Laíse Mattiollo, Jéssica Nardi, Karen Júlia de Souza dos Santos, Natália Freddo, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato‐Grando   +9 more
wiley   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Emerging Aluminum‐Ion Capacitors and Lessons from Battery Chemistry

Small, EarlyView.
Al‐ion energy storage is gaining momentum as demand grows for safer, lower‐cost, and more sustainable alternatives to Li‐based technologies. Aluminum's abundance, recyclability, and trivalent charge offer high charge capacity and scalable device potential.
Smita Talande, Ievgen Obraztsov, Vishal Shrivastav, Mahima Khandelwal, Mansi, Michal Otyepka, Radek Zbořil, Aristides Bakandritsos   +7 more
wiley   +1 more source

An Enantioselective Alkene Aminoarylation to Form Chiral Indolines via Electrostatically‐Directed Palladium Catalysis

Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.
Enantioselective aminoarylation of ortho‐allyl anilines is achieved under mild conditions. Key to success is the electrostatically‐directed nature of the key aminopalladation step, achieved by using the sulfonated chiral ligand sSPhos on palladium. A detailed study of electronic trends allows tuning of the sulfonamide protecting group to enable good ...
Max Kadarauch, Paul T. Jirsch, H. Erik Diepers, Hamzah Sharif, Robert J. Phipps   +4 more
wiley   +2 more sources