Results 91 to 100 of about 249,747 (277)

Expanding the Scope of 1,2‐Diazepines Through Alternative Activation Strategies

European Journal of Organic Chemistry, EarlyView.
Often overlooked due to tedious synthetic routes, 1,2‐diazepines can be found in handful of biorelevant molecules. Previous reports from our group lifted the principal synthetic lock: a rapid and user‐friendly protocol to reach monocyclic 1,2‐diazepines from readily available pyridines and electrophilic activating groups. Herein, we extend the scope of
Alexis Leblais, Diego Robles, Aurélie Damond, Xavier Moreau, Clément Ghiazza   +4 more
wiley   +1 more source

Direct Synthesis of C-Substituted [RC(O)CH₂-CB₁₁H₁₁]⁻ Carborate Anions

Inorganics
A new synthetic method for the synthesis of C-substituted [RC(O)CH2-CB11H11]− carborate anions has been developed. The reaction of [closo-B11H11]2− with terminal alkynes in the presence of a copper catalyst leads to insertion into the boron cluster, and ...
Vanessa C. Barra, Eduard Bernhardt, Sarah Fellinger, Carsten Jenne, Shiomi S. Langenbach   +4 more
doaj   +1 more source

2,2-Dichloro-N-(3-nitrophenyl)acetamide

Acta Crystallographica Section E, 2008
The conformation of the N—H bond in the structure of the title compound (3NPDCA), C8H6Cl2N2O3, is anti to the meta-nitro group, similar to that in the structures of 2-chloro-N-(3-nitrophenyl)acetamide (3NPCA) and 2,2,2-trichloro-N-(3-nitrophenyl ...
Hartmut Fuess, Sabine Foro, B. Thimme Gowda   +2 more
doaj   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Synthesis and crystal structure of N-phenyl-2-(phenylsulfanyl)acetamide

Acta Crystallographica Section E: Crystallographic Communications
N-Phenyl-2-(phenylsulfanyl)acetamide, C14H13NOS, was synthesized and structurally characterized. In the crystal, N—H...O hydrogen bonding leads to the formation of chains of molecules along the [100] direction.
Reham A. Mohamed-Ezzat, Benson M. Kariuki, Galal H. Elgemeie   +2 more
doaj   +1 more source

Synthesis and characterization of isothiocyanato complexes of dioxotungsten(VI) with mannich base ligands: Precursors for the preparation of pure phase nanosized tungsten(VI) trioxide

Journal of Saudi Chemical Society, 2016
Six isothiocyanato complexes of dioxotungsten(VI) with Mannich base ligands having the formula [WO2(NCS)2L-L] (where L-L = N-[1-morpholinobenzyl] acetamide (MBA), N-[1-piperidinobenzyl] acetamide (PBA), N-[1-morpholino(-4-nitrobenzyl)] benzamide (MPNBB),
Rimpy Gupta, Haq N. Sheikh, Bansi L. Kalsotra, Vishal Singh   +3 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Synthesis, crystal structure and Hirshfeld surface analysis of N-(2,6-dimethylphenyl)-2-morpholinoacetamide, a Lidocaine analog

Acta Crystallographica Section E: Crystallographic Communications
In the title molecule, C14H20N2O2, the dihedral angle between the mean plane of the phenyl ring and that defined by the ipso-C—NH—(C= O)—CH2— unit is 66.59 (11)°. The morpholine unit adopts a chair conformation. In the crystal, N—H...O hydrogen bonds and
Imane Maimoune, Abderrazzak El Moutaouakil Ala Allah, Benson M. Kariuki, Abdulsalam Alsubari, Joel T. Mague, Abdelkader Zarrouk, Youssef Ramli   +6 more
doaj   +1 more source

2-[4-Benzyl-5-(2-furyl)-4H-1,2,4-triazol-3-ylsulfanyl]acetamide

Acta Crystallographica Section E, 2008
In the title compound, C15H14N4O2S, the phenyl ring is inclined at 70.25 (6)° with respect to the approximately planar furyl–triazolsulfanyl–acetamide unit.
Muhammad Zareef, Rashid Iqbal, Muhammad Arfan, Masood Parvez   +3 more
doaj   +1 more source

Breeding switchgrass for reduced nitrogen demand

Grassland Research, EarlyView.
Breeding has improved switchgrass biomass yield, but productivity is still heavily dependent on nitrogen fertilizer application. The genetic diversity needed to improve nitrogen use efficiency of switchgrass remains underused, mainly because of the slow and laborious breeding process, thus leaving the crop's high nitrogen demand as a major barrier to ...
Michael D. Casler, Prabin Bajgain
wiley   +1 more source