Results 31 to 40 of about 258,318 (261)

The Mode of Protonation of Amides [PDF]

, 1958
The relative basicities of oxygen versus nitrogen in amides is a problem which has not been satisfactorily resolved. However, it might be anticipated from considerations of resonance and structural parameters that in strongly acidic solutions the proton ...
Fraenkel, Gideon, Niemann, Carl
core   +1 more source

Crystal structure of 2-cyano-N-(furan-2-ylmethyl)-3-(3-nitrophenyl)propanamide

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C15H11N3O4, the acetamide group is inclined to the furan ring by 66.5 (1)°. The dihedral angle between the furan ring and the benzene ring is 66.8 (1)°.
Shivanna Subhadramma, Budanur Papaiah Siddaraju, Naveen Chandra, Janardhanan Saravanan, Dasararaju Gayathri   +4 more
doaj   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Crystal structures and Hirshfeld surface analyses of 2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]-N-(pyridin-2-yl)acetamide and 2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]-N-(pyrazin-2-yl)acetamide

Acta Crystallographica Section E: Crystallographic Communications, 2018
In the title compounds, C11H12N6OS (I) and C10H11N7OS (II), the diaminopyrimidine ring makes dihedral angles of 71.10 (9)° with the pyridine ring in (I) and 62.93 (15)° with the pyrazine ring in (II).
Manisha Choudhury, Vijayan Viswanathan, Ajay Kumar Timiri, Barij Nayan Sinha, Venkatesan Jayaprakash, Devadasan Velmurugan   +5 more
doaj   +1 more source

Application of a novel tool for diagnosing bile acid diarrhoea [PDF]

, 2013
Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose. We have tested the efficacy of a new method to identify BAD, based on the detection of differences in volatile organic compounds (VOC) in urine headspace of BAD vs.
Arasaradnam, Arasaradnam, Arasaradnam, Arasaradnam, Arasaradnam, Catherine Bailey, Chuka Nwokolo, Covington, Eric Westenbrink, Fauci, Gardner, James Covington, James Cullis, Karna Bardhan, Marchesi, Nathalie Ouaret, Nicola O'Connell, Nigel Williams, Ramesh Arasaradnam, Ruth Harbord, Smith, Talley, Walters, Wilson   +23 more
core   +3 more sources

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
core   +2 more sources

RaPID Selection of Backbone Macrocyclic Peptides Targeting Akt2

Angewandte Chemie, EarlyView.
Backbone macrocyclic peptide library (BMP) library was screened against Akt2 via RaPID to discover potent BMPPakti‐3 (IC50 = 34 nM). ABSTRACT Backbone‐cyclic peptides (BMPs) are an attractive class of molecules appeared in diverse natural bioactive products. However, mRNA display technology coupled with ribosomal synthesis is intrinsically inapplicable
Koki Shinbara, Ekishin Yanagi, Ayaka Aizawa, Takayuki Katoh, Hiroaki Suga   +4 more
wiley   +2 more sources

Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue)

Acta Crystallographica Section E: Crystallographic Communications
In the title molecule, C13H17N3O3, the substituents on the phenyl ring are rotated slightly out of the mean plane of the ring but the piperidine moiety is nearly perpendicular to that plane. In the crystal, C—H...O hydrogen bonds form chains of molecules
Imane Maimoune, Benson M. Kariuki, Abderrazzak El Moutaouakil Ala Allah, Intissar Nchioua, Abdulsalam Alsubari, Joel T. Mague, Abdelkader Zarrouk, Youssef Ramli   +7 more
doaj   +1 more source

Origin of broad polydispersion in functionalized dendrimers and its effects on cancer cell binding affinity

, 2010
Nanoparticles with multiple ligands have been proposed for use in nanomedicine. The multiple targeting ligands on each nanoparticle can bind to several locations on a cell surface facilitating both drug targeting and uptake.
Bradford G. Orr, D. Weitman, Douglas G. Mullen, G. D. Titskii, Jack N. Waddell, Leonard M. Sander, Mark M. Banaszak Holl, X. Wang   +7 more
core   +1 more source

Broadband Geodesic Pulses for Three Spin Systems: Time-Optimal Realization of Effective Trilinear Coupling Terms and Indirect SWAP Gates

, 2003
Broadband implementations of time-optimal geodesic pulse elements are introduced for the efficient creation of effective trilinear coupling terms for spin systems consisting of three weakly coupled spins 1/2.
Barenco, Bennet, Cory, Ernst, Gershenfeld, Glaser, Glaser, Khaneja, Khaneja, Kim, Levitt, Linden, Marx, Meissner, Morris, Mádi, Navin Khaneja, Reiss, Schulte-Herbrüggen, Steffen J. Glaser, Sørensen, Timo O. Reiss, Tseng   +22 more
core   +2 more sources